High prevalence of antiphospholipid antibodies in children with idiopathic cerebral ischemia.
High prevalence of antiphospholipid antibodies in children with idiopathic cerebral ischemia.
复制标题
特发性脑缺血儿童抗磷脂抗体的患病率较高。
DOI：
10.1542/peds.94.4.500
复制
发表时间：
1994
期刊：
影响因子：
8
通讯作者：
A. Martini
中科院分区：
文献类型：
--
作者：
L. Angelini;A. Ravelli;R. Caporali;V. Rumi;N. Nardocci;A. Martini
背景
循环抗磷脂抗体（aPL）的存在经常与血栓栓塞现象相关。
目标
旨在调查一组未经选择的特发性脑缺血儿童中 aPL 的患病率，以狼疮抗凝物 (LA) 或抗心磷脂抗体 (aCL) 的形式检测。
设计
前瞻性，案例系列。
设置
小儿神经内科。
患者
13 名患有脑缺血的儿童（8 名患有中风，3 名患有短暂性脑缺血发作，2 名患有眼部缺血）。年龄匹配、表面健康的儿童作为对照。
测量值
LA 和 aCL 测定在缺血事件发生后 3 天内进行，并在 3 至 6 个月后重复测定。要定义为 aPL 阳性，患者必须在两项测定中 LA 测试呈阳性或 IgG 和/或 IgM aCL 呈中/高水平阳性。
主要结果
13 名患者中有 10 名 (76%) LA 或 aCL 呈阳性。 aPL 阳性和 aPL 阴性患者在临床表现或放射学特征方面没有发现差异。 13 名患者中有 6 名 (46%) 有多次缺血事件史。
结论
我们的结果显示，特发性脑缺血儿童中 aPL 的患病率非常高。由于这些抗体的存在具有相关的治疗意义，因此建议对患有脑缺血的儿童进行测定。
BACKGROUND
The presence of circulating antiphospholipid antibodies (aPLs) is frequently associated with thromboembolic phenomena.
OBJECTIVE
To investigate the prevalence of aPLs, detected as lupus anticoagulant (LA) or anticardiolipin antibody (aCL), in a group of unselected children with idiopathic cerebral ischemia.
DESIGN
Prospective, case series.
SETTING
A pediatric neurology department.
PATIENTS
Thirteen children with cerebral ischemia (eight with stroke, three with transient ischemic attacks, and two with ocular ischemia). Age-matched apparently healthy children served as controls.
MEASUREMENTS
LA and aCL determination was performed within 3 days after the occurrence of the ischemic event and was repeated after 3 to 6 months. To be defined as aPL-positive, patients had to have either a positive LA test or positive IgG and/or IgM aCL at moderate/high level in both determinations.
MAIN RESULTS
Ten (76%) of the 13 patients were positive for either LA or aCL. No differences were found between aPL-positive and aPL-negative patients with respect to clinical manifestations or radiological features. Six (46%) of the 13 patients had a history of multiple ischemic events.
CONCLUSIONS
Our results show a very high prevalence of aPLs in children with idiopathic cerebral ischemia. Because the presence of these antibodies has relevant therapeutic implications, their determination in children with cerebral ischemia is recommended.