Aqueous humor levels of topically applied levofloxacin in human eyes
Aqueous humor levels of topically applied levofloxacin in human eyes
复制标题
局部使用左氧氟沙星在人眼中的房水水平
DOI：
10.1076/ceyr.24.5.403.8517
复制
发表时间：
2002
影响因子：
2
通讯作者：
Y. Mashima
中科院分区：
文献类型：
--
作者：
M. Yamada;H. Mochizuki;Kyoko Yamada;M. Kawai;Y. Mashima
目的.评价局部应用0.5%左氧氟沙星经角膜渗透到人眼房水中。方法. 20例白内障患者（14例女性，6例男性）在术前90分钟开始接受3滴0.5%左氧氟沙星，间隔15分钟。在白内障手术开始时，从前房吸出50 μL的房水并储存在-80 ° C下直至分析。使用高效液相色谱法分析样品的药物浓度。结果左氧氟沙星的平均房水水平为1.00 ± 0.48 µg/mL（平均值±标准差，n = 20），范围为0.30 µg/mL至2.32 µg/mL。结论.左氧氟沙星在房水中的平均浓度高于对术后眼内炎的一些常见病原体的MIC 90值，尽管存在很大程度的患者间变异性。
Purpose. To evaluate transcorneal penetration of topically applied 0.5% levofloxacin into the aqueous humor in human eyes. Methods. Twenty cataract patients (14 females, 6 males) received 3 drops of 0.5% levofloxacin at 15 min intervals from 90 minutes before the surgery. At the beginning of the cataract surgery, 50 µL of aqueous humor was aspirated from the anterior chamber and stored at -80°C until analysis. The drug concentration of the samples was analyzed using high-performance liquid chromatography. Results. A mean aqueous humor level of levofloxacin was 1.00 ± 0.48 µg/mL (mean ± standard deviation, n = 20), ranging from 0.30 µg/mL to 2.32 µg/mL. Conclusions. The mean concentration of levofloxacin in the aqueous humor was higher than the MIC 90 values against some common pathogens of postoperative endophthalmitis, although a great degree of interpatient variability was present.