Treatment planning for heavy-ion radiotherapy:: calculation and optimization of biologically effective dose
Treatment planning for heavy-ion radiotherapy:: calculation and optimization of biologically effective dose
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DOI：
10.1088/0031-9155/45/11/314
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发表时间：
2000-11-01
影响因子：
3.5
通讯作者：
Scholz, M
中科院分区：
文献类型：
--
作者：
Krämer, M;Scholz, M
我们描述了一种基于局部效应模型(LEM)的重离子放射治疗计划的新方法，该模型不仅可以计算靶区的生物有效剂量，而且可以计算整个照射体积的生物有效剂量。LEM非常适合作为治疗计划代码系统的组成部分，用于主动剂量成形设备，如GSI光栅扫描系统。因此，它已被纳入我们的离子疗法(TRIP)标准治疗计划系统。单强度调制场可以相对于均匀的生物有效剂量进行优化。对于患者CT的每个体素，分别计算相对生物有效性(RBE)。我们面向放射生物学的代码系统自1995年以来一直用于计划细胞培养和动物(如大鼠和小型猪)的辐射实验。自1997年以来，它一直被定期并成功地用于患者的治疗计划。
We describe a novel approach to treatment planning for heavy-ion radiotherapy based on the local effect model (LEM) which allows us to calculate the biologically effective dose not only for the target region but also for the entire irradiation volume. LEM is ideally suited for use as an integral part of treatment planning code systems for active dose shaping devices like the GSI raster scan system. Thus it has been incorporated into our standard treatment planning system for ion therapy (TRiP). Single intensity modulated fields can be optimized with respect to a homogeneous biologically effective dose. The relative biological effectiveness (RBE) is calculated separately for each voxel of the patient CT. Our radiobiologically oriented code system has been used since 1995 for the planning of irradiation experiments with cell cultures and animals such as rats and minipigs. It has been in regular and successful use for patient treatment planning since 1997.