SEQUENTIAL STRATEGY TO IDENTIFY A SUSCEPTIBILITY GENE FOR SCHIZOPHRENIA - REPORT OF POTENTIAL LINKAGE ON CHROMOSOME 22Q12-Q13.1 .1.
SEQUENTIAL STRATEGY TO IDENTIFY A SUSCEPTIBILITY GENE FOR SCHIZOPHRENIA - REPORT OF POTENTIAL LINKAGE ON CHROMOSOME 22Q12-Q13.1 .1.
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DOI：
10.1002/ajmg.1320540108
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发表时间：
1994-03-15
期刊：
影响因子：
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通讯作者：
CHILDS, B
中科院分区：
文献类型：
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作者：
PULVER, AE;KARAYIORGOU, M;CHILDS, B
为了确定对精神分裂症易感性负责的基因，并检验精神分裂症在病因上异质性的假设，我们从精神分裂症患者的系统样本中研究了39个多重家族。使用复杂的常染色体显性模型，只考虑那些被诊断为精神分裂症或分裂情感性障碍的人，对基因组进行随机搜索以检测连锁。两两连锁分析表明，一个区域（22q12-q13.1）存在潜在连锁（LRH = 34.7或最大负载评分= 1.54）。重新分析，在主导模型中改变参数，最大LRH为660.7（最大负载评分2.82）。这一发现值得通过合作研究进行进一步调查。(C) 1994 Wiley-Liss, Inc。
To identify genes responsible for the susceptibility for schizophrenia, and to test the hypothesis that schizophrenia is etiologically heterogeneous, we have studied 39 multiplex families from a systematic sample of schizophrenic patients. Using a complex autosomal dominant model, which considers only those with a diagnosis of schizophrenia or schizoaffective disorder as affected, a random search of the genome for detection of Linkage was undertaken. Pairwise linkage analyses suggest a potential linkage (LRH = 34.7 or maximum lod score = 1.54) for one region (22q12-q13.1). Reanalyses, varying parameters in the dominant model, maximized the LRH at 660.7 (maximum lod score 2.82). This finding is of sufficient interest to warrant further investigation through collaborative studies. (C) 1994 Wiley-Liss, Inc.