A single dose of interleukin-31 (IL-31) causes continuous itch-associated scratching behaviour in mice
A single dose of interleukin-31 (IL-31) causes continuous itch-associated scratching behaviour in mice
复制标题
DOI：
10.1111/exd.12222
复制
发表时间：
2013-10-01
影响因子：
3.6
通讯作者：
Saito, Saburo
中科院分区：
文献类型：
--
作者：
Arai, Iwao;Tsuji, Minoru;Saito, Saburo
我们研究了单剂量的小鼠白细胞介素-31（IL-31）对抓挠行为的影响，并与NC/Nga和BALB/c小鼠自发皮肤损伤或5-HT诱导的抓挠行为进行了比较。皮内（i.d.）IL-31的注射在给药后约3 h引起持续抓挠（LLS，超过1.5s）的逐渐增加，随后在给药后超过24 h逐渐降低。I.D.注射IL-31显著增加了总LLS计数/24小时，但不增加短持续抓挠（SLS，0.3-1.5s）。在皮肤损伤的NC/Nga小鼠中，LLS而不是SLS计数显著高于非皮肤损伤的NC/Nga小鼠。我们还研究了5-HT诱导的BALB/c小鼠抓挠，SLS而不是LLS在注射后立即增加，然后在20分钟后降至基线。这些结果表明，IL-31可能参与瘙痒的感觉，并促进皮肤损伤的NC/Nga小鼠（特应性皮炎（AD）的动物模型）的抓挠行为。
We investigated the effects of a single dose of mouse interleukin-31 (IL-31) on scratching behaviour in comparison with spontaneous skin-lesion- or serotonin (5-HT)- induced scratching behaviour in NC/Nga and BALB/c mice. Intradermal (i.d.) injection of IL-31 caused a gradual increase in long-lasting scratching (LLS, over 1.5s) about 3h after administration followed by a gradual decrease for over 24h after administration. I.d. injection of IL-31 significantly increased the total LLS counts/24h but not short-lasting scratching (SLS, 0.3-1.5s). In skin-lesioned NC/Nga mice, the LLS but not SLS counts were significantly higher than those in non-skin-lesioned NC/Nga mice. We also investigated 5-HT-induced scratching in BALB/c mice, SLS but not LLS increased immediately after the injection and then decreased to baseline after at 20min. These results suggest that IL-31 may participate in the sensation of itching and promote scratching behaviour in skin-lesioned NC/Nga mice, an animal model of atopic dermatitis (AD).