CRTH2, an orphan receptor of T-helper-2-cells, is expressed on basophils and eosinophils and responds to mast cell-derived factor(s)
CRTH2, an orphan receptor of T-helper-2-cells, is expressed on basophils and eosinophils and responds to mast cell-derived factor(s)
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DOI：
10.1016/s0014-5793(99)01251-x
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发表时间：
1999-10-08
期刊：
影响因子：
3.5
通讯作者：
Takano, S
中科院分区：
文献类型：
--
作者：
Nagata, K;Hirai, H;Takano, S
我们最近克隆了一个假定的趋化因子受体，命名为CRTH2，这是优先表达的人辅助性T细胞（Th）2，而不是Th1细胞。在这项研究中，我们证明，CRTH2也高度表达外周血嗜碱性粒细胞和嗜酸性粒细胞。我们对CRTH2配体的研究发现，当用抗Fc β R1抗体刺激时，肥大细胞可能是配体的生产者。脐带血来源的肥大细胞分泌的因子在表达CRTH2的K562细胞中诱导Ca2+动员，但在模拟转染的细胞中不诱导。这些发现暗示CRTH2参与肥大细胞介导的免疫应答，如过敏反应。(C)1999年欧洲生物化学学会联合会。
We have recently cloned a putative chemoattractant receptor, named CRTH2, which is preferentially expressed on human T-helper- (Th) 2 but not Th1 cells. In this study, we demonstrated that CRTH2 is also highly expressed on peripheral blood basophils and eosinophils. Our search for a CRTH2 ligand identified mast cells as the possible producers of a ligand, When stimulated with an anti-Fc epsilon R1 antibody. cord blood-derived mast cells secreted factor(s) that induced Ca2+ mobilization in CRTH2-expressing K562 cells but not in mock transfected cells. These findings implied the involvement of CRTH2 in mast cell-mediated immune responses such as allergic reactions. (C) 1999 Federation of European Biochemical Societies.