N-3 ESSENTIAL FATTY-ACIDS DECREASE WEIGHT-GAIN IN GENETICALLY-OBESE MICE
N-3 ESSENTIAL FATTY-ACIDS DECREASE WEIGHT-GAIN IN GENETICALLY-OBESE MICE
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DOI：
10.1079/bjn19860088
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发表时间：
1986-07-01
影响因子：
3.6
通讯作者：
HORROBIN, DF
中科院分区：
文献类型：
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作者：
CUNNANE, SC;MCADOO, KR;HORROBIN, DF
1.瘦（ln/ln）和肥胖（ob/ob）小鼠给予含有100 g月见草（月见草报春花）油（脂肪酸18：2n-6、18：3 n-6; EPO）或100 g鱼肝油（20：5 n-3、22：6 n-3; CLO）/kg饮食的脂肪源的饮食。2.在喂食CLO的ob/ob小鼠中，体重增加较低，这一效应与食物摄入无关。3.在喂食CLO的ob/ob小鼠中，与喂食EPO的ob/ob小鼠相比，通过凝血血小板合成的血栓素减少。4. ob/ob CLO喂养小鼠的肝脏、棕色脂肪组织和白色脂肪组织中花生四烯酸较低，但n-3脂肪酸水平较高。5.因此，CLO中的n-3脂肪酸取代了组织脂质中的n-6脂肪酸，并减少了“2系列”野牡丹素的合成，此外还导致CLO喂养的ob/ob小鼠体重增加较低。
1. Lean (ln/ln) and obese (ob/ob) mice were given diets containing a fat source of 100 g evening primrose (Oenothera biennis) oil (fatty acids 18:2n-6, 18:3n-6; EPO) or 100 g cod liver oil (20:5n-3, 22:6n-3; CLO)/kg diet. 2. Weight gain was lower in the ob/ob mice fed on CLO, an effect unrelated to food intake. 3. In ob/ob mice fed on CLO, thromboxane synthesis by clotting platelets was reduced compared with that in ob/ob mice fed on EPO. 4. The ob/ob CLO-fed mice had lower arachidonic acid but higher levels of n-3 fatty acids in liver, brown adipose tissue and white adipose tissue. 5. Then n-3 fatty acids in CLO therefore replaced the n-6 fatty acids in tissue lipids and reduced synthesis of ''2 series'' prostaglandins in addition to causing lower weight gain in the CLO-fed ob/ob mice.