Photoacoustic tomography of tissue subwavelength microstructure with a narrowband and low frequency system
Photoacoustic tomography of tissue subwavelength microstructure with a narrowband and low frequency system
复制标题
窄带低频系统组织亚波长微结构光声断层扫描
DOI：
10.1063/1.4736994
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发表时间：
2012-07-16
影响因子：
4
通讯作者：
Liu, Xiaojun
中科院分区：
文献类型：
--
作者：
Yang, Yiqun;Wang, Shaohua;Liu, Xiaojun
在分析了生物组织亚波长显微结构与光声信号光谱参数之间关系的基础上，设计了一种窄带低频成像方案，用于生物组织亚波长显微结构的成像。实验结果表明，该方法可以区分两个黑色素瘤样样品的亚波长显微结构，其结构尺度（49和199 μm）远小于成像系统的工作波长0.3-1.5 mm。由于微观结构是组织特征的有效指标，因此所提出的成像方案可能具有对不同组织类型进行分类并实现深层组织中的改进诊断的潜力。
Based on the analyzed relationship between the microstructure and the spectral parameters of photoacoustic signal, a tomography scheme with a narrowband and low frequency is designed to evaluate the subwavelength microstructure of tissues. Experiments show that this approach can differentiate the subwavelength microstructures of two melanomas-like samples, where their structure scales (49 and 199 μm) are much smaller than the working wavelength 0.3–1.5 mm of the imaging system. Since the microstructure is an effective indicator to tissue characteristics, the proposed imaging scheme could have the potential to classify different tissue types and achieve improved diagnosis in deep tissues.