Nanocarriers-Mediated Drug Delivery Systems for Anticancer Agents: An Overview and Perspectives.
Nanocarriers-Mediated Drug Delivery Systems for Anticancer Agents: An Overview and Perspectives.
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DOI：
10.2147/ijn.s289443
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发表时间：
2021
影响因子：
8
通讯作者：
Ijaz M
中科院分区：
文献类型：
--
作者：
Edis Z;Wang J;Waqas MK;Ijaz M;Ijaz M
在过去的几年里，纳米技术被积极地整合为药物载体，用于治疗各种癌症。癌症临床治疗的主要障碍是对化疗药物产生多药耐药。为了克服化疗的局限性，研究人员一直在开发技术进步，通过使化疗药物能够以更高的药物含量水平输送到靶点，从而在肿瘤治疗方面取得重大进展。几种为肿瘤靶向设计的纳米药物传递系统在临床前和临床试验中进行了评估，并在癌症的临床治疗中显示出良好的结果。该综述描述了纳米载体在治疗不同类型癌症中的重要性，并着重介绍了纳米载体在药物输送和癌症纳米治疗中的应用。它还强调了基于纳米载体的递送系统的最新进展，包括聚合物纳米载体、胶束、纳米管、树枝状大分子、磁性纳米颗粒、固体脂质纳米颗粒和量子点(量子点)。讨论了纳米载体基复合材料的结构、特性及其在肿瘤治疗中的应用。最后，对纳米载体在化疗领域面临的挑战和未来的探索机会进行了展望。
Nanotechnology has been actively integrated as drug carriers over the last few years to treat various cancers. The main hurdle in the clinical management of cancer is the development of multidrug resistance against chemotherapeutic agents. To overcome the limitations of chemotherapy, the researchers have been developing technological advances for significant progress in the oncotherapy by enabling the delivery of chemotherapeutic agents at increased drug content levels to the targeted spots. Several nano-drug delivery systems designed for tumor-targeting are evaluated in preclinical and clinical trials and showed promising outcomes in cancerous tumors’ clinical management. This review describes nanocarrier’s importance in managing different types of cancers and emphasizing nanocarriers for drug delivery and cancer nanotherapeutics. It also highlights the recent advances in nanocarriers-based delivery systems, including polymeric nanocarriers, micelles, nanotubes, dendrimers, magnetic nanoparticles, solid lipid nanoparticles, and quantum dots (QDs). The nanocarrier-based composites are discussed in terms of their structure, characteristics, and therapeutic applications in oncology. To conclude, the challenges and future exploration opportunities of nanocarriers in chemotherapeutics are also presented.