Inhibition of HDAC6 activity in kidney diseases: a new perspective.
Inhibition of HDAC6 activity in kidney diseases: a new perspective.
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肾脏疾病中 HDAC6 活性的抑制：新视角
DOI：
10.1186/s10020-018-0027-4
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发表时间：
2018-06-26
期刊：
影响因子：
--
通讯作者：
Yang L
中科院分区：
文献类型：
--
作者：
Ke B;Chen Y;Tu W;Ye T;Fang X;Yang L
组蛋白脱乙酰基酶6（HDAC 6）是一种在许多生物过程中起重要作用的细胞质酶，是HDAC酶家族的一种同工型，其催化从蛋白质中去除功能性乙酰基。HDAC6从该家族的其他成员中脱颖而出，因为它几乎完全使细胞质蛋白脱乙酰化并发挥脱乙酰化独立作用，这导致成功开发了其酶促作用的相对异构体特异性抑制剂。最近许多研究表明，HDAC6表达和活性在肾脏疾病中增加，例如常染色体显性遗传性多囊肾病（ADPKD），肾纤维化和急性肾损伤（阿基）等。此外，已经研究了HDAC6抑制剂用于治疗这些疾病。事实上，HDAC6抑制剂有效地限制了肾脏疾病的进展，这表明靶向HDAC6可能提供一种新的治疗方法。然而，开发HDAC6靶向治疗的主要挑战是了解如何选择性地利用NDAC6抑制剂的肾保护作用。在这里，我们讨论了HDAC6的独特功能，并概括了其抑制剂在肾脏疾病中的诱人潜力。
Histone deacetylase 6 (HDAC6), a cytoplasmic enzyme that plays important roles in many biological processes, is one isoform of a family of HDAC enzymes that catalyse the removal of functional acetyl groups from proteins. HDAC6 stands out from the other members of this family because it almost exclusively deacetylates cytoplasmic proteins and exerts deacetylation-independent effects, which has led to the successful development of relatively isoform-specific inhibitors of its enzymatic action. Numerous studies have recently demonstrated that HDAC6 expression and activity are increased in kidney disease, such as autosomal dominant polycystic kidney disease (ADPKD), renal fibrosis, and acute kidney injury (AKI), among others. Moreover, HDAC6 inhibitors have been investigated for use in treating these diseases. In fact, HDAC6 inhibitors effectively limit the progression of kidney diseases, suggesting that targeting HDAC6 may provide a novel treatment approach. However, the primary challenge in developing HDAC6-targeted therapies is understanding how the renoprotective effect of NDAC6 inhibitors can be selectively harnessed. Here, we discuss the unique function of HDAC6 and recapitulate the alluring potential of its inhibitors in kidney diseases.
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DOI：
10.1097/ta.0000000000000510
发表时间：
2015-02
期刊：
The journal of trauma and acute care surgery
影响因子：
--
作者：
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