Trichosanthin interacts with and enters cells via LDL receptor family members
Trichosanthin interacts with and enters cells via LDL receptor family members
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DOI：
10.1006/bbrc.2000.2441
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发表时间：
2000-04-13
影响因子：
3.1
通讯作者：
Nielsen, MS
中科院分区：
文献类型：
--
作者：
Chan, WL;Shaw, PC;Nielsen, MS
i型核糖体失活蛋白trichosanthin表现出选择性的细胞毒性，表明其进入细胞的特定机制。在这里，我们发现trichosanthin特异性地与内吞受体LRP和meggalin结合，并且这种结合以及被细胞摄取受到受体相关蛋白（RAP）的抑制。结果表明，已知的天花粉蛋白的流产和肾毒性作用分别是由lrp介导的滋养细胞摄取和巨噬蛋白介导的近端小管上皮细胞摄取引起的，(C) 2000学术出版社。
The type-I ribosome-inactivating protein trichosan-thin displays selective cytotoxicity, suggesting specific mechanisms for entry into cells, Here we show that trichosanthin binds specifically to the endocytic receptors LRP and megalin, and that binding as well as uptake into cells is inhibited by the receptor-associated protein (RAP). The results suggest that the known abortifacient and renotoxic actions of trichosanthin are caused by LRP-mediated uptake in trophoblasts and megalin-mediated uptake in proximal tubule epithelial cells, respectively, (C) 2000 Academic Press.