The 3D Genome as Moderator of Chromosomal Communication.
The 3D Genome as Moderator of Chromosomal Communication.
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DOI：
10.1016/j.cell.2016.02.007
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发表时间：
2016-03-10
期刊：
影响因子：
64.5
通讯作者：
Mirny L
中科院分区：
文献类型：
--
作者：
Dekker J;Mirny L
基因的正确表达需要与位于染色体沿着其他地方的调控元件进行交流。染色质纤维的物理学对这种通信施加了一系列限制。建立或阻止染色体通讯的分子和生物物理机制已成为深入研究的主题，染色体空间组织的重要作用正在被发现。在这里，我们提出了一个观点的间期3D基因组的特点是广泛的物理分隔和绝缘的一方面，促进远程相互作用的另一方面。我们提出存在的拓扑机器致力于建立和利用一个三维基因组组织，以促进和审查通信沿着和染色体之间。
Proper expression of genes requires communication with their regulatory elements that can be located elsewhere along the chromosome. The physics of chromatin fibers imposes a range of constraints on such communication. The molecular and biophysical mechanisms by which chromosomal communication is established, or prevented, have become a topic of intense study, and important roles for the spatial organization of chromosomes are being discovered. Here we present a view of the interphase 3D genome characterized by extensive physical compartmentalization and insulation on the one hand and facilitated long-range interactions on the other. We propose the existence of topological machines dedicated to set up and to exploit a 3D genome organization to both promote and censor communication along and between chromosomes.