INVITRO STUDIES INTO THE RELEASE OF CHLORHEXIDINE ACETATE, PREDNISOLONE SODIUM-PHOSPHATE, AND PREDNISOLONE ALCOHOL FROM COLD CURE DENTURE BASE ACRYLIC
INVITRO STUDIES INTO THE RELEASE OF CHLORHEXIDINE ACETATE, PREDNISOLONE SODIUM-PHOSPHATE, AND PREDNISOLONE ALCOHOL FROM COLD CURE DENTURE BASE ACRYLIC
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DOI：
10.1002/jbm.820160207
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发表时间：
1982-01-01
期刊：
影响因子：
--
通讯作者：
THAW, M
中科院分区：
文献类型：
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作者：
ADDY, M;THAW, M
研究了醋酸氯己定、泼尼松龙磷酸钠和泼尼松龙醇从冷固化丙烯酸义齿基托材料中的释放。药物以10%wt/wt与材料的粉末相一起加入。将浓度为材料单体相的10、20和30%的水加入到含氯己定和不含氯己定的样品中。释放氯己定的分光光度计和生物测定测量表明，延长交付至140天。通过向材料中加入水来增加每日释放速率，并且在30%水掺入下，释放更大并且增加至190天。泼尼松龙磷酸钠的释放模式与不加水的洗必泰相似。泼尼松龙酒精释放的时间要短得多，水平也较低。材料抛光、蚀刻和断裂表面的扫描电子显微镜检查表明，醋酸氯己定和泼尼松龙磷酸钠被掺入材料的珠间基质区域。材料中的不规则性随着水的加入而增加。泼尼松龙酒精产生的标本中的变化最小，但在水中浸泡140天后，可以看到许多小的缺陷，在高放大率的基质区。使用诸如水的材料来增加孔隙率似乎是改善药物从丙烯酸的释放模式的简单方法。所得材料的强度将需要来自现有口内假体或器具的支撑。
The release of chlorhexidine acetate, prednisolone sodium phosphate and prednisolone alcohol from a cold cured acrylic denture base material was studied. The drugs were added at 10% wt/wt with the powder phase of the material. Water, at the concentrations of 10, 20 and 30% of the monomer phase of the material was added to chlorhexidine-containing and chlorhexidine-free samples. Spectrophotometric and bioassay measurements of the release of chlorhexidine demonstrated protracted delivery to 140 days. The daily release rate was increased by the addition of water to the material and at 30% water incorporation the release was greater and increased up to 190 days. The release pattern of prednisolone sodium phosphate was similar to that of chlorhexidine without the addition of water. Prednisolone alcohol was released for a much shorter period and at lower levels. Scanning electron microscopic examination of the polished, etched and fractured surfaces of the material demonstrated that chlorhexidine acetate and prednisolone sodium phosphate were incorporated into the interbead matrix areas of the material. The irregularities in the material increased with the addition of water. Prednisolone alcohol produced minimal changes in the specimens except after soaking in water for 140 days when numerous small defects could be seen in the matrix zones at high magnification. The use of materials such as water to increase porosity appears a simple method of improving the release pattern of drugs from acrylic. The strength of the resulting material would require support from an existing intraoral prosthesis or appliance.