Prevalence and Implications of Frailty in Older Adults With Incident Inflammatory Bowel Diseases: A Nationwide Cohort Study.
Prevalence and Implications of Frailty in Older Adults With Incident Inflammatory Bowel Diseases: A Nationwide Cohort Study.
复制标题
DOI：
10.1016/j.cgh.2022.01.001
复制
发表时间：
2022-10
期刊：
影响因子：
--
通讯作者：
中科院分区：
文献类型：
--
作者：
We aimed to compare the risk of frailty in older adults with incident inflammatory bowel disease (IBD) and matched non-IBD comparators and assess the association between frailty and future hospitalizations and mortality. In a cohort of patients with incident IBD ≥60 years from 2007–2016 in Sweden identified using nationwide registers, we defined frailty using Hospital Frailty Risk Score (HFRS). We compared prevalence of frailty in patients with IBD to age, sex, place-of-residency and calendar-year matched population comparators. In the IBD cohort, we used Cox proportional hazards modeling to examine the associations between frailty risk and hospitalizations or mortality. We identified 10,590 patients with IBD, 52% female with a mean age of 71 years, matched to 103,398 population-based comparators. Among patients with IBD, 39% had no risk for frailty, 49% had low risk and 12% had higher risk for frailty. Mean HFRS was 1.9 in IBD and 0.9 in matched-comparators (p<0.01). Older adults with IBD at higher risk for frailty had a 20% greater risk for mortality at 3 years compared with those who were not frail. Compared to non-frail older patients with IBD, patients at higher risk for frailty had increased mortality (HR:3.22, 95%confidence interval (CI): 2.86–3.61), all-cause hospitalization (HR:2.42,95%CI: 2.24–2.61) and IBD-related hospitalization (HR: 1.50,95%CI: 1.35–1.66). These associations were not attenuated after adjusting for comorbidities. Frailty is more prevalent in older adults with IBD than matched comparators. Among older patients with IBD, frailty is associated with increased risk for hospitalizations and mortality.
登录
查看更多内容
影响因子：
3.9
作者：
Ludvigsson JF;Appelros P;Askling J;Byberg L;Carrero JJ;Ekström AM;Ekström M;Smedby KE;Hagström H;James S;Järvholm B;Michaelsson K;Pedersen NL;Sundelin H;Sundquist K;Sundström J
通讯作者：
Sundström J
影响因子：
6.3
作者：
Mak JKL;Kuja-Halkola R;Wang Y;Hägg S;Jylhävä J
通讯作者：
Jylhävä J
影响因子：
6.2
作者：
Extermann, Martine;Boler, Ivette;Balducci, Lodovico
通讯作者：
Balducci, Lodovico
影响因子：
35.7
作者：
Alatab, Sudabeh;Sepanlou, Sadaf G.;Naghavi, Mohsen
通讯作者：
Naghavi, Mohsen
影响因子：
3.1
作者：
Faye AS;Wen T;Soroush A;Ananthakrishnan AN;Ungaro R;Lawlor G;Attenello FJ;Mack WJ;Colombel JF;Lebwohl B
通讯作者：
Lebwohl B