Thioredoxin Reductase Is a Valid Target for Antimicrobial Therapeutic Development Against Gram-Positive Bacteria.
Thioredoxin Reductase Is a Valid Target for Antimicrobial Therapeutic Development Against Gram-Positive Bacteria.
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硫氧还蛋白还原酶是针对革兰氏阳性细菌的抗菌治疗开发的有效靶标。
DOI：
10.3389/fmicb.2021.663481
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发表时间：
2021
影响因子：
5.2
通讯作者：
Fuchs BB
中科院分区：
文献类型：
--
作者：
Felix L;Mylonakis E;Fuchs BB
There is a drought of new antibacterial compounds that exploit novel targets. Thioredoxin reductase (TrxR) from the Gram-positive bacterial antioxidant thioredoxin system has emerged from multiple screening efforts as a potential target for auranofin, ebselen, shikonin, and allicin. Auranofin serves as the most encouraging proof of concept drug, demonstrating TrxR inhibition can result in bactericidal effects and inhibit Gram-positive bacteria in both planktonic and biofilm states. Minimal inhibitory concentrations are on par or lower than gold standard medications, even among drug resistant isolates. Importantly, existing drug resistance mechanisms that challenge treatment of infections like Staphylococcus aureus do not confer resistance to TrxR targeting compounds. The observed inhibition by multiple compounds and inability to generate a bacterial genetic mutant demonstrate TrxR appears to play an essential role in Gram-positive bacteria. These findings suggest TrxR can be exploited further for drug development. Examining the interaction between TrxR and these proof of concept compounds illustrates that compounds representing a new antimicrobial class can be developed to directly interact and inhibit the validated target.
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DOI：
10.1016/j.bbagen.2016.03.013
发表时间：
2016-06-01
影响因子：
3
作者：
Gustafsson, Tomas N.;Osman, Harer;Holmgren, Arne
通讯作者：
Holmgren, Arne
影响因子：
27.4
作者：
FINKELSTEIN, AE;WALZ, DT;MISHER, A
通讯作者：
MISHER, A
影响因子：
4.8
作者：
Bonilla, Mariana;Denicola, Ana;Salinas, Gustavo
通讯作者：
Salinas, Gustavo
影响因子：
5.4
作者：
Dwivedi, Ved Prakash;Bhattacharya, Debapriya;Das, Gobardhan
通讯作者：
Das, Gobardhan
大肠杆菌双精氨酸易位（TAT）抑制剂的高吞吐量筛选。
影响因子：
3.7
作者：
Bageshwar UK;VerPlank L;Baker D;Dong W;Hamsanathan S;Whitaker N;Sacchettini JC;Musser SM
通讯作者：
Musser SM