Low-dimensional maps encoding dynamics in entorhinal cortex and hippocampus.
Low-dimensional maps encoding dynamics in entorhinal cortex and hippocampus.
复制标题
编码内嗅皮层和海马体动态的低维图。
DOI：
10.1162/neco.2006.18.11.2617
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发表时间：
2006
影响因子：
2.9
通讯作者：
Kopell,NancyJ
中科院分区：
文献类型：
--
作者：
Pervouchine,DmitriD;Netoff,TheodenI;Rotstein,HoracioG;White,JohnA;Cunningham,MarkO;Whittington,MilesA;Kopell,NancyJ
产生内在 theta 振荡的细胞通常包含超极化激活电流 Ih。在本文中，我们使用模型和动态钳实验来研究具有快速尖峰（FS）中间神经元的网络中两个此类细胞（内嗅皮层的星状细胞和海马的 O-LM 细胞）的同步特性。我们用于星状细胞和 O-LM 细胞的模型是相同的，但星状细胞是兴奋性的，而 O-LM 细胞是抑制性的，抑制性突触后电位比 FS 中间神经元的突触后电位要长得多。我们使用尖峰时间响应曲线方法（STRC），将该技术扩展到三细胞网络，并给出两种不同的方法，将三细胞网络的分析简化为两细胞网络的分析。我们证明，将 FS 细胞添加到星状细胞网络中可以使星状细胞去同步，而将它们添加到 O-LM 细胞网络中可以同步 O-LM 细胞。这些同步和去同步特性主要取决于 Ih。对确定性系统的分析使我们能够了解噪声对星状网络中相位关系的一些影响。动态钳实验使用生物物理星状细胞和计算机模拟 FS 细胞，具有模拟激发或抑制的连接，后者具有与 FS 细胞或 O-LM 细胞相关的衰减时间。动态钳实验获得的结果与分析框架非常吻合。
Cells that produce intrinsic theta oscillations often contain the hyperpolarization-activated current Ih. In this article, we use models and dynamic clamp experiments to investigate the synchronization properties of two such cells (stellate cells of the entorhinal cortex and O-LM cells of the hippocampus) in networks with fast-spiking (FS) interneurons. The model we use for stellate cells and O-LM cells is the same, but the stellate cells are excitatory and the O-LM cells are inhibitory, with inhibitory postsynaptic potential considerably longer than those from FS interneurons. We use spike time response curve methods (STRC), expanding that technique to three-cell networks and giving two different ways in which the analysis of the three-cell network reduces to that of a two-cell network. We show that adding FS cells to a network of stellate cells can desynchronize the stellate cells, while adding them to a network of O-LM cells can synchronize the O-LM cells. These synchronization and desynchronization properties critically depend on Ih. The analysis of the deterministic system allows us to understand some effects of noise on the phase relationships in the stellate networks. The dynamic clamp experiments use biophysical stellate cells and in silico FS cells, with connections that mimic excitation or inhibition, the latter with decay times associated with FS cells or O-LM cells. The results obtained in the dynamic clamp experiments are in a good agreement with the analytical framework.