Voltage-dependent K+ currents in guinea pig Müller (glial) cells show different sensitivities to blockade by Ba2+
Voltage-dependent K+ currents in guinea pig Müller (glial) cells show different sensitivities to blockade by Ba2+
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豚鼠 Müller（神经胶质）细胞中电压依赖性 K+ 电流对 Ba2+ 阻断表现出不同的敏感性
DOI：
10.1016/0304-3940(93)90663-6
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发表时间：
1993
影响因子：
2.5
通讯作者：
T. Pannicke
中科院分区：
文献类型：
--
作者：
W. Reichelt;T. Pannicke
用全细胞膜片钳技术研究了外源性Ba ~（2+）和Na ~+对豚鼠视网膜Müller细胞K ~+电流的影响。Müller细胞表达一组典型的K+电流，即欧姆电流、失活内向电流（IK（IR））、延迟整流电流（IK（DR））和失活外向电流（IK（A））。当细胞外Na+被胆碱取代时，内向电流不发生失活。当给药浓度增加时，Ba ~（2+）以典型的顺序阻断这些K ~+电流：欧姆电流和IK（A）最敏感，其次是IK（IR），而IK（DR）即使在1 mM Ba ~（2+）中也不能完全阻断。Müller细胞K+电流对外部Ba 2+的不同敏感性可能是一种工具，可用于提高我们对视网膜生理刺激的Müller细胞反应的理解。
The effect of externally applied Ba2+and Na+on K+currents was investigated by means of whole-cell patch-clamp in isolated and in situ Müller cells from guinea pig retina. Müller cells express a typical set of K+currents, i.e. an ohmic current, an inactivating inward current (IK(IR)), a delayed rectifier (IK(DR)) and an inactivating outward current (IK(A)). Inactivation of the inward current did not occur when extracellular Na+was replaced by choline. When administered in increasing concentrations, Ba2+blocked these K+currents in a typical sequence: the ohmic current andIK(A)were most sensitive, followed byIK(IR), whereasIK(DR)was not completely blocked even in 1 mM Ba2+. The differential sensitivity of Müller cell K+currents to external Ba2+may be a tool which can be used to improve our understanding of the Müller cell response to physiological stimulation of the retina.
影响因子：
2.5
作者：
R. H. Steinberg;B. Oakley;G. Niemeyer
通讯作者：
R. H. Steinberg;B. Oakley;G. Niemeyer
影响因子：
56.9
作者：
KARWOSKI, CJ;LU, HK;NEWMAN, EA
通讯作者：
NEWMAN, EA