Comorbidities of Atopic Dermatitis: Beyond Rhinitis and Asthma.
Comorbidities of Atopic Dermatitis: Beyond Rhinitis and Asthma.
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DOI：
10.1007/s13671-017-0168-7
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发表时间：
2017
影响因子：
1.6
通讯作者：
Thyssen JP
中科院分区：
文献类型：
--
作者：
Andersen YMF;Egeberg A;Skov L;Thyssen JP
在这篇综述文章中，我们总结了目前关于特应性皮炎（AD）相关合并症的证据，超越了传统的特应性和过敏性疾病。AD患者患心血管疾病、某些恶性肿瘤、自身免疫性疾病和神经精神疾病的风险可能会增加。这些关联的原因可能是多因素的，可能包括遗传易感性、全身性低度炎症、环境暴露、药物治疗以及生活方式和行为风险因素。AD患者合并症的患病率似乎存在地理差异，表明种族和生活方式因素的差异可能会显著影响某些合并症的风险。最近文献中报告的合并症强调了AD患者的疾病负担。早期适当的AD治疗，结合减少风险因素，可能有助于预防某些合并症。报告的观察结果可能会为未来对AD相关合并症的潜在风险因素的研究产生假设。
In this review article, we summarize the current evidence about atopic dermatitis (AD)-associated comorbidities, beyond the traditional atopic and allergic conditions. Patients with AD may have an increased risk of cardiovascular diseases, certain malignancies, autoimmune diseases, and neuropsychiatric diseases. The causes of these associations are likely multifactorial and may include genetic predispositions, systemic low-grade inflammation, environmental exposures, medication, and lifestyle and behavioral risk factors. There appears to be geographical variations in prevalence of comorbidities in patients with AD, indicating that differences in ethnicity and lifestyle factors may significantly influence the risk of certain comorbidities. The reported comorbidities in recent literature emphasize the burden of disease in patients with AD. Early appropriate AD therapy, in combination with reduction of risk factors, may help prevention of certain comorbidities. The reported observations may generate hypotheses for future investigations in underlying risk factors for AD-associated comorbidities.