Role of the autonomic nervous system in mild human hypertension.
Role of the autonomic nervous system in mild human hypertension.
复制标题
自主神经系统在人类轻度高血压中的作用。
DOI：
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发表时间：
1975
期刊：
影响因子：
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通讯作者：
O. Randall
中科院分区：
文献类型：
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作者：
S. Julius;M. Esler;O. Randall
1. 轻度（临界）人类高血压的一些血流动力学异常似乎是神经源性的，因为它们可以通过药物自主神经阻断完全消除。 2. 30% 的患者通过增加交感神经驱动和减少副交感神经抑制而提高心输出量。 3. 在其余情况下，较高的血压是通过增加总外周血管阻力来维持的。 4. 在后一组中大约 30% 的人中，较高的血管阻力仅通过增加 α-肾上腺素能张力来维持。 5. 部分病例血浆肾素活性升高可能是由于交感神经活动普遍增加所致。 6.因此，患有轻度高血压的患者表现出对心脏和小动脉的交感神经驱动增加以及心脏副交感神经抑制减少。据推测血浆肾素增加也是神经源性的。 7. 自主神经张力改变如此广泛的分布表明心血管控制综合中心的功能失常。 8. 有证据表明，在某些情况下，这些变化可能是由心身引起的。
1. Some of the haemodynamic abnormalities in mild (borderline) human hypertension appear to be neurogenic, since they can be completely abolished by pharmacological autonomic blockade. 2. The cardiac output is elevated in 30% of patients through increased sympathetic drive and decreased parasympathetic inhibition. 3. In the remainder, the higher blood pressure is maintained by increased total peripheral vascular resistance. 4. In approximately 30% of this latter group, the higher vascular resistance is maintained solely by increased alpha-adrenergic tone. 5. Elevated plasma renin activities in a proportion of cases are probably due to generalized increase in sympathetic nervous activity. 6. Patients with mild hypertension thus show increased sympathetic drive to the heart and arterioles as well as decreased cardiac parasympathetic inhibition. It is presumed that the increased plasma renin is also neurogenic. 7. Such a widespread distribution of altered autonomic tone suggests aberration of the function of the integrative centres of cardiovascular control. 8. Evidence is presented of a possible psychosomatic origin of these changes in some cases.