Menstrual Cycle in Women Who Co-use Marijuana and Tobacco.
Menstrual Cycle in Women Who Co-use Marijuana and Tobacco.
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同时吸食大麻和烟草的女性的月经周期。
DOI：
10.1097/adm.0000000000000387
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发表时间：
2018
影响因子：
5.5
通讯作者：
Allen,Sharon
中科院分区：
文献类型：
--
作者：
Lammert,Sara;Harrison,Katherine;Tosun,Nicole;Allen,Sharon
目的：大麻是美国最常用的非法药物，与烟草的共同使用正在增加。初步研究表明，大麻可能抑制黄体生成素（LH）或缩短黄体期。尽管文献混杂，但这些性激素可能在戒烟结果中发挥作用。这项次要亚组分析旨在探讨在寻求烟草治疗的个体样本中，同时使用大麻和烟草的女性与只使用烟草的女性的月经周期。方法：年龄在18岁至50岁之间、自我报告月经周期规律、大麻和烟草共同使用的女性参与者与只使用烟草的参与者按年龄比例为1:3。卵泡期和黄体期的长度用第一反应尿液LH试验确定。使用Wilcoxon 2样本t检验来确定组间相长度的差异。结果：13名同时使用大麻和烟草的女性和39名只使用烟草的女性被纳入本分析。总体而言，参与者年龄为37.3±8.0 （SD）岁，主要是高加索人（67%），每天吸烟12.6±5.2 （SD）支。同时使用大麻和烟草的受试者黄体期长度（11.4天±2.2天[SD]）显著短于仅使用烟草的受试者（16.8天±11.3天[SD]； P= 0.002）。在卵泡期长度和月经周期长度方面没有发现差异。结论：这些数据表明，与只使用烟草的女性相比，同时使用大麻和烟草的女性可能有更短的黄体期。需要进一步的研究来更好地了解大麻的使用如何影响月经周期和吸烟的结果。
Objective:Marijuana is the most commonly used illicit drug in the United States and co-use with tobacco is increasing. Preliminary studies have indicated that marijuana may suppress luteinizing hormone (LH) or shorten the luteal phase. Although the literature is mixed, these sex hormones may play a role in smoking cessation outcomes. This secondary subgroup analysis aims to explore the menstrual cycle of females who co-use marijuana and tobacco compared with females who only use tobacco in a sample of tobacco treatment-seeking individuals.Methods:Female participants, aged 18 to 50 years, who self-reported regular menstrual cycles and co-use of marijuana and tobacco were matched 1: 3 by age to participants who only use tobacco. Length of the follicular and luteal phases was determined using First Response Urine LH tests. Wilcoxon 2-sample t tests were used to determine differences in phase lengths between groups.Results:Thirteen women who co-use marijuana and tobacco, and 39 women who only use tobacco were included in this analysis. Overall, participants were 37.3±8.0 (SD) years of age, mostly Caucasian (67%), and smoked 12.6±5.2 (SD) cigarettes per day. The luteal phase length among participants who co-use marijuana and tobacco (11.4 days±2.2 [SD]) was significantly shorter than among participants who only use tobacco (16.8 days±11.3 [SD]; P= 0.002). No differences were found in follicular phase length or menstrual cycle length.Conclusions:These data suggest that females who co-use marijuana and tobacco may have a shortened luteal phase in comparison with females who only use tobacco. Further studies are needed to better understand how marijuana use may impact the menstrual cycle and affect smoking outcomes.