Short-term changes on C-reactive protein (CRP) levels after non-surgical periodontal treatment in systemically healthy individuals
Short-term changes on C-reactive protein (CRP) levels after non-surgical periodontal treatment in systemically healthy individuals
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DOI：
10.1007/s00784-016-1817-0
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发表时间：
2017-01-01
影响因子：
3.4
通讯作者：
Araujo, Mauricio G.
中科院分区：
文献类型：
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作者：
de Souza, Andre Barbisan;Okawa, Rogerio T. P.;Araujo, Mauricio G.
本研究的目的是评价慢性牙周炎患者和牙周健康者血清C反应蛋白（CRP）水平，并评估牙周非手术治疗对CRP水平的影响。（实验组）和22名牙周健康者（对照组），两组均无任何全身性疾病或潜在混杂因素，均纳入本研究。在基线时，牙周临床变量和CRP水平在两组。试验组进行口腔卫生指导、洁治和根面平整，60天后复查牙周临床变量和CRP水平，试验组基线CRP水平显著高于对照组相应值（1.98 ± 1.55 vs. 1.26 ± 1.05 mg/L; p < 0.05）。实验组牙周治疗后各项牙周临床指标均有改善（p < 0.05）。基线CRP水平较高（> 3 mg/L）的患者CRP水平明显降低，慢性牙周炎可能促进CRP水平升高。此外，非手术牙周治疗仅在CRP水平高的患者中显著降低CRP水平。牙周炎可能是改变CVD风险的潜在因素。因此，由卫生专业人员进行的牙周感染控制可以改善心血管健康。
The aim of the present study was to evaluate serum C-reactive protein (CRP) levels in chronic periodontitis patients and periodontally healthy individuals and to assess the effect of non-surgical periodontal treatment on the CRP levels.Twenty-two patients with chronic periodontitis (test group) and 22 periodontally healthy individuals (control group), both groups without any systemic disorder or potential confounding factors, were included in the study. At baseline, periodontal clinical variables and CRP levels were obtained in both groups. In the test group, oral hygiene instruction and scaling and root planning were carried out; then, after 60 days, periodontal clinical variables and CRP levels were reevaluated.The baseline CRP level in the test group was significantly higher than the corresponding value in the control group (1.98 +/- 1.55 vs. 1.26 +/- 1.05 mg/L; p < 0.05). After periodontal treatment in the test group, there were improvements in all periodontal clinical variables (p < 0.05). The CRP level decreased significantly in those patients with higher baseline levels of CRP (> 3 mg/L).Chronic periodontitis seemed to promote elevated levels of CRP. Furthermore, non-surgical periodontal treatment significantly decreased the levels of CRP only in patients with high baseline levels of such pro-inflammatory cytokine.Periodontitis may be a potential factor to change the risk of CVD. Thus, the control of periodontal infection performed by health professionals may improve cardiovascular health.