Global Functional Connectivity Deficits in Schizophrenia Depend on Behavioral State
Global Functional Connectivity Deficits in Schizophrenia Depend on Behavioral State
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DOI：
10.1523/jneurosci.2987-11.2011
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发表时间：
2011-09
期刊：
影响因子：
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通讯作者：
R. Salomon;M. Bleich-Cohen;Avital Hahamy-Dubossarsky;Ilan Dinstien;R. Weizman;M. Poyurovsky;M. Kupchik;M. Kotler;T. Hendler;R. Malach
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文献类型：
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作者：
R. Salomon;M. Bleich-Cohen;Avital Hahamy-Dubossarsky;Ilan Dinstien;R. Weizman;M. Poyurovsky;M. Kupchik;M. Kotler;T. Hendler;R. Malach
精神分裂症是一种毁灭性的精神疾病，其特征是认知和情绪处理能力恶化。据推测，异常的皮质连接与该疾病有关（Friston，1998），但之前对精神分裂症功能连接（FC）的研究显示了不同的结果（Garrity 等，2007；Jafri 等，2008；Lynall 等，2010）。我们使用 fMRI 测量了人类精神分裂症患者和健康对照组在两种不同任务和休息条件下的 FC，并构建了基于体素的全局 FC 指数。我们发现与对照组相比，患者的 FC 显着下降。在任务条件下，相对较弱的 FC 特定于任务期间不活跃的皮层区域。在休息状态下，患者和对照组之间的 FC 差异较大，并且可以根据具体情况区分两组个体。结果表明，精神分裂症患者 FC 的相对减少取决于皮质活动的状态，未被任务激活的体素显示出较高水平的 FC 缺乏。这一新发现可能有助于阐明之前有关精神分裂症 FC 的报道。这种神经特征是否与疾病的发展有关仍有待确定。
Schizophrenia is a devastating psychiatric illness characterized by deterioration of cognitive and emotional processing. It has been hypothesized that aberrant cortical connectivity is implicated in the disease (Friston, 1998), yet previous studies of functional connectivity (FC) in schizophrenia have shown mixed results (Garrity et al., 2007; Jafri et al., 2008; Lynall et al., 2010). We measured FC using fMRI in human schizophrenia patients and healthy controls during two different tasks and a rest condition, and constructed a voxel-based global FC index. We found a striking FC decrease in patients compared with controls. In the task conditions, relatively weaker FC was specific to regions of cortex not active during the task. In the rest condition, the FC difference between patients and controls was larger and allowed a case-by-case separation between individuals of the two groups. The results suggest that the relative reduction of FC in schizophrenia is dependent on the state of cortical activity, with voxels not activated by the task showing higher levels of FC deficiency. This novel finding may shed light on previous reports of FC in schizophrenia. Whether this neural characteristic is related to the development of the disorder remains to be established.