Dietary ursolic acid improves health span and life span in male Drosophila melanogaster
Dietary ursolic acid improves health span and life span in male Drosophila melanogaster
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DOI：
10.1002/biof.1467
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发表时间：
2019-03-01
期刊：
影响因子：
6
通讯作者：
Rimbach, Gerald
中科院分区：
文献类型：
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作者：
Staats, Stefanie;Wagner, Anika E.;Rimbach, Gerald
黑腹果蝇的健康和寿命部分取决于肠道屏障的完整性、代谢率、应激反应和长寿相关基因的表达，这取决于遗传和饮食因素。熊果酸（UA）是一种天然存在的三萜，具有潜在的抗菌、抗炎和抗肥胖活性，并能抵消与年龄相关的肌肉力量缺陷。在本研究中，给w(1118) D. melanogaster喂食UA，显著延长了雄性的健康和寿命。Spargel （srl）是哺乳动物过氧化物酶体增殖激活受体- γ辅助激活因子1 α (PGC1 α)的果蝇同源物，是能量稳态和线粒体功能的重要调节剂。我们的研究结果表明，UA的健康促进作用，通过显著增加攀爬活动来证明，是通过上调srl表达导致苍蝇的代谢转变而发生的，而不会降低繁殖力或肠道完整性。此外，UA以一种有助于延长寿命的方式影响果蝇的微生物群。Srl的表达和微生物群似乎都受到UA的影响，正如我们通过使用Srl突变体和无菌果蝇所确定的那样。(c)中国生物医学工程学报，2018,35 (2):389 - 389,2019
The health and life span of Drosophila melanogaster are partly determined by intestinal barrier integrity, metabolic rate as well as stress response and the expression of longevity-associated genes, depending on genetic and dietary factors. Ursolic acid (UA) is a naturally occurring triterpenoid exhibiting potential antimicrobial, anti-inflammatory, and antiobesity activity and counteracting age-related deficits in muscle strength. In this study, UA was dietarily administered to w(1118) D. melanogaster which significantly elongated the health and life span of males. Spargel (srl) is the Drosophila orthologue of mammalian peroxisome proliferator-activated receptor-gamma coactivator 1 alpha(PGC1 alpha), an important regulator of energy homeostasis and mitochondrial function. Our results indicate that the health-promoting effect of UA, demonstrated by a significant increase in climbing activity, occurs via an upregulation of srl expression leading to a metabolic shift in the fly without reducing fecundity or gut integrity. Moreover, UA affected the flies' microbiota in a manner that contributed to life span extension. Srl expression and microbiota both seem to be affected by UA, as we determined by using srl-mutant and axenic flies. (c) 2018 BioFactors, 45(2):169-186, 2019