Perfusion-related parameters in intravoxel incoherent motion MR imaging compared with CBV and CBF measured by dynamic susceptibility-contrast MR technique
Perfusion-related parameters in intravoxel incoherent motion MR imaging compared with CBV and CBF measured by dynamic susceptibility-contrast MR technique
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DOI：
10.1080/028418501127346459
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发表时间：
2001-03-01
期刊：
影响因子：
1.3
通讯作者：
Ståhlberg, F
中科院分区：
文献类型：
--
作者：
Wirestam, R;Borg, M;Ståhlberg, F
Objective.将体素内非相干运动（IVIM）MR成像（MRI）获得的灌注相关参数与动态磁共振成像（DSC）获得的脑血容量和血流灌注（CBV和CBF）进行比较。采用IVIM编码梯度的自旋回波回波平面回波成像（36个不同的B值，0-1200 s/mm（2））。使用渐近和完全拟合计算丘脑灰质和额叶白色物质区域的灌注分数和伪扩散系数。在DSC-MRI中，使用双FLASH监测Gd-DTPA-BMA造影剂团注。结果：脑血流灌注分数与CBV的相关系数r = 0.56（p <0.01），与CBV的相关系数r = 0.56（p <0.01），与CBV的相关系数r = 0.56（p <0.01），与CBV的相关系数r= 0.56（p <0.01），与CBF的相关系数r=0.56（p <0.01），与CBV的相关系数r=0.56（p <0.01），与CBV的相关系数r=0.56（p <0.01），与CBF的相关系数r=0.56（p <0.01），与CBV的相关系数r =0.56（p <0.01）。
Objective. Perfusion-related parameters obtained by intravoxel incoherent motion (IVIM) MR imaging (MRI) were compared with cerebral blood volume and how (CBV and CBF), retrieved by dynamic susceptibility-contrast (DSC) MRI.Material and Methods: Twenty-eight volunteers (average age 68.5 years) were investigated. Spin-echo echo-planar imaging with IVIM-encoding gradients was employed (36 different b values, 0-1200 s/mm(2)). The perfusion fraction and the pseudo-diffusion coefficient were calculated for regions in thalamus gray matter and frontal white matter, using asymptotic and full fitting. In DSC-MRI, a Gd-DTPA-BMA contrast-agent bolus was monitored using simultaneous-dual FLASH. Deconvolution of the measured tissue concentration-versus-time curve with an arterial input function from the carotid artery was applied, and maps of CBV and CBF were calculated.Results: The correlation between the perfusion fraction and CBV was r=0.56 (p