Graft-versus-host disease of the central nervous system after liver transplantation: A rare complication
Graft-versus-host disease of the central nervous system after liver transplantation: A rare complication
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DOI：
10.1111/ajt.14981
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发表时间：
2018-10-01
影响因子：
8.8
通讯作者：
Salgia, Reena
中科院分区：
文献类型：
--
作者：
Pahari, Hirak;Nagai, Shunji;Salgia, Reena
移植物抗宿主病（GVHD）的中枢神经系统（CNS）的实体器官移植是一种罕见的，但严重的并发症，以前曾报告后骨髓移植。肝移植后GVHD是一种罕见的实体，死亡率高。我们报告的情况下，病人谁发展GVHD，随后有癫痫发作和改变后，已故供体肝移植的精神状态。采用聚合酶链反应技术和基因定位软件对脑脊液进行短串联重复序列位点分析，诊断CNS GVHD。据我们所知，这是第一次报告的情况下，中枢神经系统移植物抗宿主病肝移植。他最终死于败血症和多器官功能衰竭，符合整体预后不良的CNS-GVHD。移植物抗宿主病的中枢神经系统肝移植后是一种罕见的并发症，可以通过短串联重复序列分析的脑脊液诊断，但往往是危及生命的，符合整体预后不良的这种疾病。
Graft-versus-host disease (GVHD) of the central nervous system (CNS) following solid organ transplantation is a rare but serious complication and has been previously reported after bone marrow transplantation. GVHD after liver transplantation is a rare entity with a high mortality rate. We report the case of a patient who developed GVHD and subsequently had seizures and altered mental status after deceased donor liver transplantation. The diagnosis of GVHD of the CNS was established by short tandem repeat loci analysis of the cerebrospinal fluid using the polymerase chain reaction technique and gene mapping software. To our knowledge, this is the first reported case of CNS-GVHD following liver transplantation. He eventually died of sepsis and multiorgan failure, in keeping with the overall poor prognosis of CNS-GVHD.Graft-versus-host disease of the central nervous system following liver transplantation is a rare complication that can be diagnosed by short tandem repeat analysis of the cerebrospinal fluid, but is often life-threatening, in keeping with the overall poor prognosis of this disease.