Pharmacokinetic study of mannitol in subjects with increased ICP.
Pharmacokinetic study of mannitol in subjects with increased ICP.
复制标题
ICP 升高受试者中甘露醇的药代动力学研究。
DOI：
10.1007/978-3-7091-9334-1_148
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发表时间：
1994
期刊：
影响因子：
--
通讯作者：
T. Ohwada
中科院分区：
文献类型：
--
作者：
T. Kobayashi;T. Ichikawa;R. Kondo;Y. Yoshiyama;F. Tomonaga;T. Ohwada
六名受试者接受甘露醇静脉滴注 (DIV)。在每个受试者中，甘露醇的浓度和血清渗透压在甘露醇施用期间迅速升高，并在甘露醇施用结束时达到最大值。然后，它呈指数下降。甘露醇浓度与外源血清渗透压之间存在很强的正相关性。中央室（Cc）和外周室（Pc）之间甘露醇浓度差的积分值与甘露醇给药期间ICP降低的变化相关。结果表明，ICP降低的变化取决于Cc和Pc之间的甘露醇浓度差。
Six human subjects received mannitol as an introvenous dip (DIV) infusion. In each subject, the concentration of mannitol and serum osmolality were rapidly elevated during mannitol administration and reached the maximum at the end of mannitol administration. Then, it exponentially decreased. There was a strong positive correlation between mannitol concentration and extrinsic serum osmolality. The integrated values of mannitol concentration difference between the central (Cc) and the peripheral compartment (Pc) correlated with the changes of ICP reduction during mannitol administration. The results indicate that the changes of ICP reduction depend on the mannitol concentration difference between Cc and Pc.