Risk factors for helicobacter pylori infection in children:: is education a main determinant?
Risk factors for helicobacter pylori infection in children:: is education a main determinant?
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DOI：
10.1017/s0950268803001572
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发表时间：
2004-04-01
影响因子：
4.2
通讯作者：
Sant'Ana, CS
中科院分区：
文献类型：
--
作者：
Moreira, ED;Santos, RS;Sant'Ana, CS
为了调查与幽门螺杆菌 (Hp) 感染相关的潜在危险因素，我们对巴西萨尔瓦多连续选取的 167 名住院儿童进行了病例对照研究。通过血清样本中存在针对 Hp 的 IgG 来鉴定 Hp 感染。使用结构化问卷收集数据，38.3% 的儿童被发现呈血清反应阳性并被归类为病例，61.7% 的儿童为血清反应阴性对照。经过多变量分析，与 Hp 感染相关的自变量包括：儿童提供者的受教育程度大于或等于 11 岁（OR 0.1，95 % CI 0.01-0.9）、垃圾处理服务差（OR 2.2，95 % CI 1.0-4.9）、吮吸拇指（OR 4.6，95 % CI 1.1-19.8）、刷牙时间超过每天一次（OR 5.6，95 % CI 1.8-17.7），养宠物狗（OR 2.5，95 % CI 1.0-6.1），有慢性荨麻疹病史（OR 4.0，95 % CI 1.5-10.8）。确定的危险因素与一些（但不是全部）之前支持幽门螺杆菌口-口或粪-口传播的研究一致。我们的数据表明，较高的教育程度可能在预防幽门螺杆菌感染方面发挥重要作用。
To investigate potential risk factors associated with Helicobacter pylori (Hp) infection, we performed a case-control study in 167 consecutively selected hospitalized children in Salvador, Brazil. Hp infection was identified by the presence of IgG against Hp in serum samples. Data were gathered using a structured questionnaire, 38.3 % children were found to be seropositive and classified as cases, and 61.7 % were seronegative controls. After multivariate analysis, independent variables associated with Hp infection included: the educational attainment of the child's provider greater than or equal to 11 years (OR 0.1, 95 % Cl 0.01-0.9), poor garbage disposal service (OR 2.2, 95 % CI 1.0-4.9), thumb sucking (OR 4.6, 95 % CI 1.1-19.8), brushing teeth more than once a day (OR 5.6, 95 % CI 1.8-17.7), having a pet dog (OR 2.5, 95 % CI 1.0-6.1), and a history of chronic urticaria (OR 4.0, 95 % CI 1.5-10.8). The risk factors identified are consistent with some, but not all, previous studies supporting either oral-oral or faecal-oral transmission of Hp. Our data suggested that a higher educational attainment might play an important role in preventing Hp infection.