Changes in network activity with the progression of Parkinson's disease-猫眼课题宝

DOI：

10.1093/brain/awm086

发表时间：

2007-07-01

期刊：

BRAIN

影响因子：

14.5

通讯作者：

中科院分区：

医学1区

文献类型：

作者：

Huang, Chaorui;Tang, Chengke;Eidelberg, David

帕金森氏病(PD)与空间分布的神经系统中的异常活动有关，这些神经系统调节这种疾病的运动和认知表现。代谢PET研究表明，这种疾病的特征是一套与这些临床特征相关的可复制的功能大脑网络。在这项纵向研究中，15名早期帕金森病患者(年龄58.0+/-10.2岁；Hoehn和Yahr分期1.2+/-0.3)在确诊后2年内入选。受试者在基线、24个月和48个月时接受了多示踪PET成像。在每个时间点，用[F-18]-氟代脱氧葡萄糖(FDG)扫描，评估局部葡萄糖利用的纵向变化，以及PD相关运动(PDRP)和认知代谢协方差模式(PDCP)的表达。在每个时间点，受试者还接受了[F-18]-氟丙基-β-CIT(FP-CIT)的PET成像，以量化尾状核和壳核多巴胺转运体(DAT)结合的纵向变化。使用统计参数图(SPM)定位三个时间点的区域代谢变化。用重复测量方差分析(RMANOVA)评估局部代谢和网络活动、丘脑/壳核DAT结合和统一帕金森病评定量表(UPDRS)运动分级的纵向变化。通过计算受试者内相关系数来评估这些疾病进展指标之间的关系。我们发现，疾病进展与丘脑底核(STN)和苍白球内侧核(GPI)代谢增加有关(P

Parkinson's disease (PD) is associated with abnormal activity in spatially distributed neural systems mediating the motor and cognitive manifestations of this disorder. Metabolic PET studies have demonstrated that this illness is characterized by a set of reproducible functional brain networks that correlate with these clinical features. The time at which these abnormalities appear is unknown, as is their relationship to concurrent clinical and dopaminergic indices of disease progression.In this longitudinal study, 15 early stage PD patients (age 58.0 +/- 10.2 years; Hoehn and Yahr Stage 1.2 +/- 0.3) were enrolled within 2 years of diagnosis. The subjects underwent multitracer PET imaging at baseline, 24 and 48 months. At each timepoint they were scanned with [F-18]-fluorodeoxyglucose (FDG) to assess longitudinal changes in regional glucose utilization and in the expression of the PD-related motor (PDRP) and cognitive metabolic covariance patterns (PDCP). At each timepoint the subjects also underwent PET imaging with [F-18]-fluoropropyl beta CIT (FP-CIT) to quantify longitudinal changes in caudate and putamen dopamine transporter (DAT) binding. Regional metabolic changes across the three timepoints were localized using statistical parametric mapping (SPM). Longitudinal changes in regional metabolism and network activity, cauclate/putamen DAT binding, and Unified Parkinson's Disease Rating Scale (UPDRS) motor ratings were assessed using repeated measures analysis of variance (RMANOVA). Relationships between these measures of disease progression were assessed by computing within-subject correlation coefficients.We found that disease progression was associated with increasing metabolism in the subthalamic nucleus (STN) and internal globus pallidus (GPi) (P

Changes in network activity with the progression of Parkinson's disease

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