Responses of Primary Afferent Fibers to Acupuncture-Like Peripheral Stimulation at Different Frequencies: Characterization by Single-Unit Recording in Rats
Responses of Primary Afferent Fibers to Acupuncture-Like Peripheral Stimulation at Different Frequencies: Characterization by Single-Unit Recording in Rats
复制标题
初级传入纤维对不同频率的针刺样外周刺激的反应：大鼠单单元记录的表征
DOI：
10.1007/s12264-020-00509-3
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发表时间：
2020-05-11
影响因子：
5.6
通讯作者：
Han, Ji-Sheng
中科院分区：
文献类型：
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作者：
Huo, Ran;Han, Song-Ping;Han, Ji-Sheng
众所周知，针灸的镇痛作用涉及初级传入神经（PAN），因为它们在向中枢神经系统传输信号中发挥着作用。利用大鼠的单单元记录，我们表征了针刺样刺激诱导的 Aβ 和 Aδ 纤维中电信号的产生和传输。使用三种技术在 PAN 中引发类针灸信号：手动针灸 (MAc)、模拟针灸 (EAc) 和类电针 (EA) 外周电刺激 (PES)。 MAc 和 EAc 引起的放电大多呈爆发模式，平均爆发内和爆发间放电率分别为 90 Hz 和 2 Hz。 PAN 中的放电频率与 PES 的频率相关。 Aβ 纤维的最高放电频率为 246 Hz，Aδ 纤维的最高放电频率为 180 Hz。因此，密集-分散模式下的 EA（交替频率在 2 Hz 和 15 Hz 之间或 2 Hz 和 100 Hz 之间）最能模拟 MAc。 EA 输出频率 >250 Hz 似乎对于缓解疼痛来说已经过时了。
The pain-relieving effect of acupuncture is known to involve primary afferent nerves (PANs)viatheir roles in signal transmission to the CNS. Using single-unit recording in rats, we characterized the generation and transmission of electrical signals in Aβ and Aδ fibers induced by acupuncture-like stimuli. Acupuncture-like signals were elicited in PANs using three techniques: manual acupuncture (MAc), emulated acupuncture (EAc), and electro-acupuncture (EA)-like peripheral electrical stimulation (PES). The discharges evoked by MAc and EAc were mostly in a burst pattern with average intra-burst and inter-burst firing rates of 90 Hz and 2 Hz, respectively. The frequency of discharges in PANs was correlated with the frequency of PES. The highest discharge frequency was 246 Hz in Aβ fibers and 180 Hz in Aδ fibers. Therefore, EA in a dense-disperse mode (at alternating frequency between 2 Hz and 15 Hz or between 2 Hz and 100 Hz) best mimics MAc. Frequencies of EA output >250 Hz appear to be obsolete for pain relief.