Aging impairs endothelium-dependent vasodilation in rat skeletal muscle arterioles.
Aging impairs endothelium-dependent vasodilation in rat skeletal muscle arterioles.
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衰老会损害大鼠骨骼肌小动脉的内皮依赖性血管舒张功能。
DOI：
10.1152/ajpheart.00004.2002
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发表时间：
2002
期刊：
影响因子：
--
通讯作者：
Delp,MichaelD
中科院分区：
文献类型：
--
作者：
Muller-Delp,JudyM;Spier,ScottA;Ramsey,MichaelW;Delp,MichaelD
Blood flow capacity in skeletal muscle declines with age. Reduced blood flow capacity may be related to decline in the maximal vasodilatory capacity of the resistance vasculature. This study tested the hypothesis that aging results in impaired vasodilatory capacity of first-order (1A) arterioles isolated from rat-hindlimb locomotory muscle: 1A arterioles (90–220 μm) from gastrocnemius and soleus muscles of young (4 mo) and aged (24 mo) Fischer-144 rats were isolated, cannulated, and pressurized via hydrostatic reservoirs. Vasodilatory responses to increasing concentrations of ACh (10−9to 10−4M), adenosine (ADO, 10−10to 10−4M), and sodium nitroprusside (SNP, 10−10to 10−4M) were evaluated at a constant intraluminal pressure of 60 cmH2O in the absence of flow. Flow-induced vasodilation was also evaluated in the absence of pressure changes. Responses to ADO and SNP were not altered by age. Endothelium-dependent vasodilation induced by flow was significantly reduced in arterioles from both gastrocnemius and soleus muscles. In contrast, endothelium-dependent vasodilation to ACh was reduced only in soleus muscle arterioles. These results indicate that aging impairs vasodilatory responses mediated through the endothelium of resistance arterioles from locomotory muscle, whereas smooth muscle vasodilatory responses remain intact with aging. Additionally, ACh-induced vasodilation was altered by age only in soleus muscle arterioles, suggesting that the mechanism of age-related endothelial impairment differs in arterioles from soleus and gastrocnemius muscles.
