The Association Between Arsenic and Children's Intelligence: A Meta-analysis
The Association Between Arsenic and Children's Intelligence: A Meta-analysis
复制标题
DOI：
10.1007/s12011-008-8298-1
复制
发表时间：
2009-06-01
影响因子：
3.9
通讯作者：
Su, Shi-Yue
中科院分区：
文献类型：
--
作者：
Dong, Ju;Su, Shi-Yue
本研究旨在调查砷暴露是否会增加中国儿童低智商 (IQ) 的风险。 MEDLINE、SCI、CNKI 和 CBM 检索了 1988 年至 2008 年间发表的所有英文和中文文献，使用以下关键词：arsenic、intelligence 和 IQ。因此，本研究纳入了四项横断面研究，评估早期接触砷的儿童智商低下的情况。当砷中毒地区或轻度砷中毒地区与非砷中毒地区进行比较时，本荟萃分析计算了智商的汇总加权平均差；分别为-6.85（95%置信区间[CI] = -8.30至-5.41；p < 0.01，使用固定效应模型）和-6.54（95% CI = -8.93至-4.15；p < 0.01，使用随机效应模型），这意味着生活在砷中毒地区或轻度砷中毒地区的儿童智商低于生活在砷中毒地区的儿童。非砷中毒地区，砷与儿童智力之间可能存在很强的关联。
This present study was undertaken to investigate whether arsenic exposure increases the risk of children's low intelligence quotient (IQ) in China. MEDLINE, SCI, CNKI, and CBM search were organized for all documents published, in English and Chinese, between 1988 and 2008 using the following keywords: arsenic, intelligence, and IQ. As a result, four cross-sectional studies that assessed the development of low IQ in children who had been exposed to arsenic earlier in their life were included in this study. The summary weighted mean difference of IQ was calculated in this meta-analyses, when arsenicosis areas or slight arsenicosis areas were compared with non-arsenicosis areas; it is -6.85 (95% confidence interval [CI] = -8.30 to -5.41; p < 0.01, using a fixed effect model) and -6.54 (95%CI = -8.93 to -4.15; p < 0.01, using a random effect model), which means that children who live in an arsenicosis area or a slight arsenicosis area have lower IQ than those who live in a non-arsenicosis area, and there may be a strong association between arsenic and children's intelligence.