Morphological characteristics and electrophysiological responses of visceral nociceptive neurons in somatosensory cerebral cortex of cat
Morphological characteristics and electrophysiological responses of visceral nociceptive neurons in somatosensory cerebral cortex of cat
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DOI：
10.1016/s0006-8993(99)01883-1
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发表时间：
1999-11-06
期刊：
影响因子：
2.9
通讯作者：
Teng, GX
中科院分区：
文献类型：
--
作者：
Chen, JH;Teng, GX
本文报道了内脏伤害性刺激激活的神经生物素标记的猫皮层神经元的形态学。本文报道了内脏大神经（GSN）代表区851个神经元的电生理特性和52个神经元的结构。内脏伤害感受神经元（viscero-nociceptive neurons，VNNs）是对刺激GSN产生强烈反应的神经元。在SI区，VNN的反应方式为兴奋性、抑制性和混合性。根据放电簇的潜伏期，VNN可分为两类。仅表现长潜伏期的神经元称为特异性VNN，具有长、短潜伏期放电簇的神经元称为非特异性VNN。在获得电生理数据后，通过电泳将神经生物素注射到一些细胞中，并研究它们在大脑皮层中的结构和位置。结果提供了有关SI区VNN形态学和电生理特征的一些发现。VNN在树突结构和轴突分布上比非内脏伤害性神经元（NVNN）具有更复杂的形态学特征。在照相机描绘中，兴奋性VNN多呈锥形，抑制性VNN多呈星状。非特异性VNN的结构可能不同于特异性VNN的树突状分布。(C)1999 Elsevier Science B. V.保留所有权利。
The morphology of intracellular neurobiotin-labeled cortical neurons activated by noxious visceral stimuli in cat was reported. The electrophysiologic properties of 851 neurons and structure of 52 neurons of representative area of the greater splanchnic nerve (GSN) in the primary somatosensory cortex were described. The neurons responding to stimulation of GSN with strong intensity were referred to as viscero-nociceptive neurons (VNNs). Patterns of the responses of VNNs in SI area were excitatory, inhibitory and mixed. According to latency of discharge clusters in response, the VNNs could be classified into two kinds. The neurons only showing long latency were called specific VNNs; those having discharge clusters with both long and short latency induced by stimulus were nonspecific VNNs. Following acquisition of electrophysiological data, neurobiotin was injected into some cells by electrophoresis and their structure and location in the cerebral cortex were studied. The results provided some findings about morphological and electrophysiological characteristics of VNNs in SI area. It is thought that VNNs have more complicated morphology in the dendritic construction and axon distribution than nonvisceral nociceptive neurons (NVNNs). Most of the excitatory VNNs showed pyramidal shape and most of the inhibitory VNNs had stellate shape in camera lucida drawing. The architecture of the nonspecific VNNs might be different from specific VNNs in dendritic distribution. (C) 1999 Elsevier Science B.V. All rights reserved.