Lipid Abnormalities and Inflammation in HIV Inflection.
Lipid Abnormalities and Inflammation in HIV Inflection.
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艾滋病毒弯曲中的脂质异常和炎症。
DOI：
10.1007/s11904-016-0321-0
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发表时间：
2016-08
影响因子：
4.6
通讯作者：
Mehta NN
中科院分区：
文献类型：
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作者：
Funderburg NT;Mehta NN
人类免疫缺陷病毒（HIV）感染以及随后的抗逆转录病毒疗法（ART）治疗通常与血脂谱的紊乱有关。此外，尽管ART抑制了病毒复制，但持续的炎症可能导致脂质组成和功能的改变，加剧了心血管疾病（CVD）的发展风险。已在HIV感染者中测量到几种促炎性脂质物质（包括氧化LDL和HDL）的水平升高，并且与免疫激活标志物相关。与这种双向关系相关的机制需要进一步研究，其中炎症增加脂质水平并促进其修饰，而这些修饰的脂质物质使炎症过程永久化。他汀类药物治疗和其他生活方式改变，包括改善饮食摄入和运动，对降低CVD风险至关重要。需要考虑设计良好的临床试验，考虑到艾滋病毒感染者体内脂质和炎症之间的复杂关系。
Infection with the human immunodeficiency virus (HIV), and subsequent treatment with antiretroviral therapy (ART), is often associated with perturbations in lipid profiles. Furthermore, persistent inflammation, in spite of suppression of viral replication by ART, likely contributes to modifications in lipid composition and function, exacerbating risk for development of cardiovascular disease (CVD). Increased levels of several pro-inflammatory lipid species, including oxidized LDL and HDL, have been measured in HIV-infected persons and are associated with markers of immune activation. The mechanisms linked to this bidirectional relationship in which inflammation increases lipid levels and promotes their modification, and these modified lipid species perpetuate inflammatory processes, require further investigation. Treatment with statins and other lifestyle modifications, including improvement in dietary intake and exercise, are critical to reducing CVD risk. Well-designed clinical trials that take into account the complex relationships among lipids and inflammation within persons infected with HIV need to be considered.