Field evaluation of the efficacy and safety of emodepside/praziquantel spot-on solution against naturally acquired nematode and cestode infections in domestic cats.
Field evaluation of the efficacy and safety of emodepside/praziquantel spot-on solution against naturally acquired nematode and cestode infections in domestic cats.
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DOI：
10.1007/s00436-005-1445-0
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发表时间：
2005-10-01
影响因子：
2
通讯作者：
Radeloff, I
中科院分区：
文献类型：
--
作者：
Altreuther, G;Buch, J;Radeloff, I
两项对照、设盲和随机化多中心临床田间研究评价了emodepside/吡喹酮滴剂治疗猫胃肠道线虫和绦虫感染的疗效和安全性。在欧洲进行的一项研究中，在接受emodepside/吡喹酮滴剂（Profender，Bayer AG，Leverkusen，德国）给药的猫中观察到所有线虫卵和猫弓蛔虫卵的粪便虫卵计数分别减少>98%。对于含有赛拉菌素（Stronectin）的阳性对照产品，观察到减少>95%。在接受emodepside/吡喹酮滴剂给药的感染绦虫的猫中观察到粪便虫卵和节片减少100%。在北美进行的一项研究中，猫接受了emodepside/吡喹酮滴剂加安慰剂片剂或分别含有赛拉菌素（Revolution）和依西太尔（Cestex）的两种对照产品的组合给药。粪便虫卵计数减少T。两种处理的cati>99%。对于犬复孔绦虫的粪便卵和节片，在接受艾莫地塞/吡喹酮滴剂给药的猫和对照组中分别记录到> 99%和>97%的减少。在欧洲研究中未观察到不良反应，仅在北美研究的两个治疗组的少数猫中观察到短期轻度不良反应。这两项研究表明，在田间条件下，emodepside/praziquantel spot-on非常有效和安全。
Two controlled, blinded and randomized multi-site clinical field studies evaluated the efficacy and safety of emodepside/praziquantel spot-on in the treatment of gastrointestinal nematode and cestode infections in cats. In a study conducted in Europe, faecal egg count reductions of >98% for all nematode eggs and eggs of Toxocara cati, respectively, were observed in cats treated with emodepside/praziquantel spot-on (Profender, Bayer AG, Leverkusen, Germany). For a positive-control product containing selamectin (Stronghold) reductions of >95% were observed. A 100% reduction of faecal eggs and proglottids was observed in cats treated with emodepside/praziquantel spot-on that were infected with cestodes. In a study conducted in North America, cats were treated with either emodepside/praziquantel spot-on plus a placebo tablet or a combination of two control products containing, respectively, selamectin (Revolution) and epsiprantel (Cestex). Faecal egg count reduction for eggs of T. cati was >99% for both treatments. For faecal eggs and proglottids of Dipylidium caninum reductions of >99 and >97% were recorded for cats treated with emodepside/praziquantel spot-on and the control group, respectively. No adverse reactions were observed in the European study, and only mild ones of short duration in a few cats from both treatment groups of the North American study. The two studies demonstrated that emodepside/praziquantel spot-on is highly efficacious and safe under field conditions.