Mode of oral iron administration and the amount of iron habitually consumed do not affect iron absorption, systemic iron utilisation or zinc absorption in iron-sufficient infants: a randomised trial
Mode of oral iron administration and the amount of iron habitually consumed do not affect iron absorption, systemic iron utilisation or zinc absorption in iron-sufficient infants: a randomised trial
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DOI：
10.1017/s0007114516003032
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发表时间：
2016-09-01
影响因子：
3.6
通讯作者：
Egli, Ines M.
中科院分区：
文献类型：
--
作者：
Szymlek-Gay, Ewa A.;Domellof, Magnus;Egli, Ines M.
补充和强化铁的不同代谢途径，或铁对锌吸收的抑制，可能解释了补充铁在铁充足的婴儿中的不良影响。我们确定了口服铁的方式或习惯摄入量是否影响婴儿的铁吸收和全身铁利用，并评估了这些干预措施对锌吸收、铁和锌状况以及生长的影响。将72名铁充足的6个月大婴儿随机分为高铁配方奶粉组、低铁配方奶粉组和不加铁配方奶粉组，分别每日摄入铁6.6mgFe、1.3mgFe、6.6mgFe和不加铁配方奶粉45d，用口服(Fe-57和Zn-67)和静脉注射(Fe-58和Zn-70)同位素测定其铁吸收、铁利用率和锌吸收。测定铁、锌营养状况、感染情况和生长情况。45d时，高铁组Hb比铁滴组高6.3g/L，高铁组和铁滴组分别比低铁组高34%和35%，血清转铁蛋白0.1g/L比低铁组低(均P
Different metabolic pathways of supplemental and fortification Fe, or inhibition of Zn absorption by Fe, may explain adverse effects of supplemental Fe in Fe-sufficient infants. We determined whether the mode of oral Fe administration or the amount habitually consumed affects Fe absorption and systemic Fe utilisation in infants, and assessed the effects of these interventions on Zn absorption, Fe and Zn status, and growth. Fe-sufficient 6-month-old infants (n 72) were randomly assigned to receive 6.6 mg Fe/d from a high-Fe formula, 1.3 mg Fe/d from a low-Fe formula or 6.6 mg Fe/d from Fe drops and a formula with no added Fe for 45 d. Fractional Fe absorption, Fe utilisation and fractional Zn absorption were measured with oral (Fe-57 and Zn-67) and intravenous (Fe-58 and Zn-70) isotopes. Fe and Zn status, infection and growth were measured. At 45 d, Hb was 6.3 g/l higher in the high-Fe formula group compared with the Fe drops group, whereas serum ferritin was 34 and 35 % higher, respectively, and serum transferrin 0.1 g/l lower in the high-Fe formula and Fe drops groups compared with the low-Fe formula group (all P