Expression of ZIC genes in the development of the chick inner ear and nervous system.
Expression of ZIC genes in the development of the chick inner ear and nervous system.
复制标题
ZIC 基因在鸡内耳和神经系统发育中的表达。
DOI：
10.1002/dvdy.10262
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发表时间：
2003
期刊：
影响因子：
--
通讯作者：
Barald,KateF
中科院分区：
文献类型：
--
作者：
Warner,StephenJ;Hutson,MaryR;Oh,Seung-Ha;Gerlach-Bank,LisaM;Lomax,MargaretI;Barald,KateF
ZICgenes, vertebrate homologues of theDrosophilapair‐rule gene odd‐paired (opa), function in embryonic pattern formation, in the early stages of central nervous system neurogenesis and in cerebellar maturation. MouseZicgenes are expressed in restricted, and in some cases overlapping, patterns during development, particularly in the central and peripheral nervous systems. We identified chickZIC2in a differential display analysis of the auditory system designed to find genes up‐regulated after noise trauma. In this study, we examined the expression of chickZIC1,ZIC2, andZIC3by in situ hybridization in normal inner ear development and in the tissues that influence its development, including the hindbrain, the neural crest, and the periotic mesenchyme. Between Hamburger and Hamilton stages 13 and 24, all three ZIC genes were found in the dorsal periotic mesenchyme adjacent to the developing inner ear.ZIC1mRNA was expressed in the otocyst epithelium between stages 12 and 24, in some sensory tissue, as well as in a striped pattern in the floorplate of the hindbrain that appears to be complementary to that of Chordin, a gene known to regulate ZIC expression in frogs. Chick ZIC genes are also expressed in the neuroectoderm, paraxial mesenchyme, brain, spinal cord, neural crest, and/or the overlying ectoderm as well as the limb buds. In general,ZIC1andZIC2expression patterns overlapped, althoughZIC2expression was less robust;ZIC3expression was minimal. These observations suggest that ZIC genes, in addition to their known roles in brain development, may play an important role in the development of the chick inner ear. Developmental Dynamics 702–712, 2003. © 2003 Wiley‐Liss, Inc.
