Vitamin D as an effective treatment approach for drug abuse and addiction
Vitamin D as an effective treatment approach for drug abuse and addiction
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DOI：
10.1016/j.jmhi.2013.02.001
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发表时间：
2013-07-01
期刊：
影响因子：
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通讯作者：
Eserian, Jaqueline Kalleian
中科院分区：
文献类型：
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作者：
Eserian, Jaqueline Kalleian
治疗药物滥用和成瘾的有效药物疗法尚未确定。有证据表明，维生素D可能参与神经发育，并可能对成人大脑中的多巴胺能通路起到神经保护作用。维生素D增加酪氨酸羟化酶表达水平的事实表明，维生素D可以调节多巴胺能过程。滥用药物通过不同的作用机制和在大脑奖励系统中的不同位置发挥作用；然而，它们都有一个共同的最终行动，即它们在奖励途径中增加多巴胺水平。与对照组相比，经维生素D处理的动物显示出显著减弱了甲基苯丙胺诱导的多巴胺和代谢物的减少，这表明维生素D为多巴胺能系统提供了保护，使其免受甲基苯丙胺的耗竭影响。在这篇文章中，我们推测维生素D将是一种有效的治疗药物滥用和成瘾的方法，如果我们认为维生素D可以为多巴胺能系统提供保护，使其免受药物的多巴胺耗竭影响，就像它对甲基苯丙胺所做的那样。这一假说可以为药物滥用和成瘾的新治疗方法提供新的方向，因为目前我们还没有药物治疗方法，尽管有几个问题需要进一步研究。(C)2013年德黑兰医科大学。爱思唯尔有限公司出版。CC BY-NC-ND许可证下的开放访问。
Effective pharmacological treatments for drug abuse and addiction have not yet been identified. Evidences show that vitamin D may be involved in neurodevelopment and may have a neuroprotective effect on dopaminergic pathways in the adult brain. The fact that vitamin D increases the levels of tyrosine hydroxylase expression implies that vitamin D could modulate dopaminergic processes. Drugs of abuse act through different mechanisms of action and on different locations in the brain reward system; however, all of them share a final action in which they increase dopamine levels in the reward pathway. Vitamin D-treated animals showed significant attenuated methamphetamine-induced reductions in dopamine and metabolites when compared to control, indicating that vitamin D provides protection for the dopaminergic system against the depleting effects of methamphetamine. In this article, it is speculated that vitamin D would be an effective treatment approach for drug abuse and addiction, if we consider that vitamin D would provide protection for the dopaminergic system against dopamine-depleting effects of drugs, as it did for methamphetamine. This hypothesis can provide a new direction towards a new treatment approach for drug abuse and addiction, as we have no pharmacological treatments at our disposal at the present moment, although several issues need further investigation. (C) 2013 Tehran University of Medical Sciences. Published by Elsevier Ltd. Open access under CC BY-NC-ND license.