Behavioral/systems/cognitive Functionally Specific Changes in Resting-state Sensorimotor Networks after Motor Learning
Behavioral/systems/cognitive Functionally Specific Changes in Resting-state Sensorimotor Networks after Motor Learning
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通讯作者：
Shahabeddin Vahdat;Mohammad Darainy;T. Milner;D. Ostry
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作者：
Shahabeddin Vahdat;Mohammad Darainy;T. Milner;D. Ostry
运动学习改变了大脑皮层运动区和皮层下区域的活动，但学习是否也影响了感觉系统？我们研究了在人类运动学习的影响，使用功能磁共振成像测量功能连接在休息条件下，发现持续的变化，涉及运动和躯体感觉区域的大脑网络。我们开发了一种技术，使我们能够区分可归因于运动学习的功能连接变化与那些与学习相关的感知变化。使用这种技术，我们确定了一个新的网络在运动学习涉及第二躯体感觉皮层，腹侧前运动皮层，和补充运动皮层的激活是特别相关的感知变化，发生在与运动学习。我们还发现了一个由小脑皮层、初级运动皮层和背侧运动前皮层组成的网络的变化，这些网络与学习的运动方面有关。在每个网络中，我们观察到神经可塑性变化与运动学习或感知功能的行为测量之间高度可靠的线性关系。因此，运动学习会导致大脑中不同的静息状态网络发生功能性变化。
Motor learning changes the activity of cortical motor and subcortical areas of the brain, but does learning affect sensory systems as well? We examined in humans the effects of motor learning using fMRI measures of functional connectivity under resting conditions and found persistent changes in networks involving both motor and somatosensory areas of the brain. We developed a technique that allows us to distinguish changes in functional connectivity that can be attributed to motor learning from those that are related to perceptual changes that occur in conjunction with learning. Using this technique, we identified a new network in motor learning involving second somato-sensory cortex, ventral premotor cortex, and supplementary motor cortex whose activation is specifically related to perceptual changes that occur in conjunction with motor learning. We also found changes in a network comprising cerebellar cortex, primary motor cortex, and dorsal premotor cortex that were linked to the motor aspects of learning. In each network, we observed highly reliable linear relationships between neuroplastic changes and behavioral measures of either motor learning or perceptual function. Motor learning thus results in functionally specific changes to distinct resting-state networks in the brain.