Contribution of non-sensory neurons in visual cortical areas to visually guided decisions in the rat
Contribution of non-sensory neurons in visual cortical areas to visually guided decisions in the rat
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DOI：
10.1016/j.cub.2021.03.099
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发表时间：
2021-07-12
期刊：
影响因子：
9.2
通讯作者：
Hirokawa, Junya
中科院分区：
文献类型：
--
作者：
Osako, Yuma;Ohnuki, Tomoya;Hirokawa, Junya
人们普遍认为，在视觉检测性能的试验由试验的可变性解释的保真度的视觉反应在视觉皮层区域的影响波动的内部状态，如警惕性和行为的历史。然而，目前尚不清楚哪些神经元集合代表了这些不同的内部状态。在这里，我们利用了视觉检测任务，区分内部状态响应相同的刺激，同时记录神经元同时从初级视觉皮层（V1）和后顶叶皮层（PPC）。我们发现，大鼠有时会扣留他们的视觉刺激的反应，尽管在V1的视觉反应的强大存在。我们的无人监督的分析显示，不同的人口动态分离命中反应失误，正交嵌入到视觉反应动态在V1和PPC。V1区和PPC区的异质性非感觉神经元对群体水平编码有显著贡献，但仅V1区存在噪声相关性调制。这些结果突出了V1和PPC中的非感觉神经元对群体水平计算的重要贡献，这些计算反映了动物的内部状态，以驱动对视觉刺激的行为反应。
It is widely assumed that trial-by-trial variability in visual detection performance is explained by the fidelity of visual responses in visual cortical areas influenced by fluctuations of internal states, such as vigilance and behavioral history. However, it is not clear which neuronal ensembles represent such different internal states. Here, we utilized a visual detection task, which distinguishes internal states in response to identical stimuli, while recording neurons simultaneously from the primary visual cortex (V1) and the posterior parietal cortex (PPC). We found that rats sometimes withheld their responses to visual stimuli despite the robust presence of visual responses in V1. Our unsupervised analysis revealed distinct population dynamics segregating hit responses from misses, orthogonally embedded to visual response dynamics in both V1 and PPC. Heterogeneous non-sensory neurons in V1 and PPC significantly contributed to population-level encoding accompanied with the modulation of noise correlation only in V1. These results highlight the non-trivial contributions of non-sensory neurons in V1 and PPC for population-level computations that reflect the animals' internal states to drive behavioral responses to visual stimuli.