Granulocyte-to-dendritic cell-ratio as marker for the immune monitoring in patients with renal cell carcinoma
Granulocyte-to-dendritic cell-ratio as marker for the immune monitoring in patients with renal cell carcinoma
复制标题
DOI：
10.1186/2001-1326-3-13
复制
发表时间：
2014-01-01
影响因子：
10.6
通讯作者：
Seliger, Barbara
中科院分区：
文献类型：
--
作者：
Riemann, Dagmar;Hase, Sabine;Seliger, Barbara
背景资料：中性粒细胞与淋巴细胞比率（NLR）已被证明是一个预测患者的结果为几种类型的malignancy.Findings：使用流式细胞术，我们寻找预测标记物来监测血液免疫细胞在肾细胞癌患者接受手术的原发肿瘤。由于标准差较高，肿瘤患者和对照组之间的术前NLR值无显著差异。与此相反，肿瘤患者的粒细胞与树突状细胞（DC）的比值显着较高的值。早期肿瘤患者和局部晚期肿瘤患者的NLR值无差异，而粒细胞/DC比值在这些组中有显著差异。此外，通过比较两组患者手术前后的粒细胞/DC比值，可以证明粒细胞/DC比值作为肿瘤患者免疫监测指标的可行性。结论：粒细胞/DC比值可以作为肿瘤患者免疫监测的一个新的生物标志物。
Background: Neutrophil-to-lymphocyte ratio (NLR) has been shown to be a predictor of patients' outcome for several types of malignancies.Findings: Using multicolor flow cytometry we searched for predictive markers to monitor blood immune cells in patients with renal cell carcinoma undergoing surgery of the primary tumor. Due to a high standard deviation, pre-surgery NLR values did not significantly differ between tumor patients and the control group. In contrast, the granulocyte-to-dendritic cell (DC) ratio revealed significant higher values in tumor patients. Whereas NLR values did not differ between patients with early stage tumors and locally advanced tumors, the granulocyte/DC ratio was significantly different in these groups. Additionally, comparison of both ratios before and after tumor resection in the two groups "open surgery" and "laparoscopy" could demonstrate the suitability of granulocyte/DC ratio as a marker for immune monitoring.Conclusions: Granulocyte/DC ratio may serve as a new putative biomarker for the immune monitoring of tumor patients.