From genes to protein structure and function: novel applications of computational approaches in the genomic era
From genes to protein structure and function: novel applications of computational approaches in the genomic era
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DOI：
10.1016/s0167-7799(99)01398-0
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发表时间：
2000-01-01
影响因子：
17.3
通讯作者：
Fetrow, JS
中科院分区：
文献类型：
--
作者：
Skolnick, J;Fetrow, JS
The genome-sequencing projects are providing a detailed 'parts list' of life. A key to comprehending this list is understanding the function of each gene and each protein at various levels. Sequence-based methods for function prediction are inadequate because of the multifunctional nature of proteins. However, just knowing the structure of the protein is also insufficient for prediction of multiple functional sites. Structural descriptors for protein functional sites are crucial for unlocking the secrets in both the sequence and structural-genomics projects.
