Solid lipid nanoparticles loaded thermoresponsive pluronic-xanthan gum hydrogel as a transdermal delivery system
Solid lipid nanoparticles loaded thermoresponsive pluronic-xanthan gum hydrogel as a transdermal delivery system
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DOI：
10.1002/app.46004
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发表时间：
2018-03-15
影响因子：
3
通讯作者：
Park, Hyun Jin
中科院分区：
文献类型：
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作者：
Lee, Min Hyeock;Shin, Gye Hwa;Park, Hyun Jin
本研究的目的是开发和研究温度响应性水凝胶纳入姜黄素（Cur）作为经皮给药系统的应用。通过超声均质化将Cur包封在固体脂质纳米颗粒内，并将这些纳米颗粒引入由普朗尼克F68（PF 68）和F127（PF 127）组成的温敏性水凝胶中。由10：90比例的PF 68和PF 127组成的水凝胶在接近皮肤温度的29.3 ℃下从溶胶转变为凝胶。含0.2%（w/w）XG的水凝胶的皮肤渗透性和粘附强度分别是不含XG的水凝胶的1.64和1.24倍。通过观察粒径、多分散指数、透射电子显微镜和扫描电子显微镜，研究了制备的制剂的理化特性。此外，傅立叶变换红外光谱分析在生理温度下进行，这表明在凝胶相比在溶胶相的氢键强度较低。与Cur乙醇溶液相比，Cur渗透的累积量显著增加。(C)2017Wiley Periodicals，Inc.
The aim of this study was to develop and investigate thermoresponsive hydrogel incorporating curcumin (Cur) for application as a transdermal delivery system. Cur was encapsulated within solid lipid nanoparticles via ultrasonic homogenization, and these were introduced into a thermoresponsive hydrogel composed of pluronic F68 (PF68) and F127 (PF127). The hydrogel composed of PF68 and PF127 in 10: 90 ratio transformed from sol to gel at 29.3 degrees C close to skin temperature. The skin adhesiveness and adhesive strength of the hydrogel with 0.2% (w/w) of XG was 1.64 and 1.24 times higher than those of the hydrogel without XG, respectively. The physiochemical characteristics of prepared formulations were investigated via observation of particle size, polydispersity index, transmission electron microscopy, and scanning electron microscopy. Moreover, Fourier transform infrared spectroscopy analysis was performed at physiological temperature, which revealed lower hydrogen bonding intensity at gel phase than at sol phase. The cumulative amount of Cur that penetrated significantly increased compared with the Cur ethanol solution. (C) 2017Wiley Periodicals, Inc.