Grape Juice, Berries, and Walnuts Affect Brain Aging and Behavior
Grape Juice, Berries, and Walnuts Affect Brain Aging and Behavior
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DOI：
10.3945/jn.109.108266
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发表时间：
2009-09-01
影响因子：
4.2
通讯作者：
Willis, Lauren M.
中科院分区：
文献类型：
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作者：
Joseph, James A.;Shukitt-Hale, Barbara;Willis, Lauren M.
大量研究表明，饮食中含有大量水果和蔬菜的人患阿尔茨海默病等与年龄相关的疾病的几率较低。我们实验室的研究表明，膳食补充富含抗氧化剂的水果或蔬菜提取物（例如蓝莓、草莓、核桃和康科德葡萄汁）可以降低衰老过程中对氧化应激的脆弱性，而这些降低表现为行为的改善。水果和蔬菜的有益作用涉及的其他机制包括通过增加神经元信号传导和减少氧化/炎症应激源（例如核因子 kB）诱导的应激信号来增强神经元通讯。此外，合作研究结果表明，患有轻度认知障碍的人类补充蓝莓或康科德葡萄汁可以提高语言记忆能力，从而将我们的动物发现转化为人类。总而言之，这些结果表明，更多地摄入浆果、康科德葡萄和核桃等高抗氧化食物可能会增加“健康寿命”，并增强衰老过程中的认知和运动功能。
Numerous studies have indicated that individuals consuming a diet containing high amounts of fruits and vegetablesexhibit fewer age-related diseases such as Alzheimer's disease. Research from our laboratory has suggested that dietarysupplementation with fruit or vegetable extracts high in antioxidants (e.g. blueberries, strawberries, walnuts, and Concordgrape juice) can decrease the enhanced vulnerability to oxidative stress that occurs in aging and these reductions areexpressed as improvements in behavior. Additional mechanisms involved in the beneficial effects of fruits and vegetablesinclude enhancement of neuronal communication via increases in neuronal signaling and decreases in stress signalsinduced by oxidative/inflammatory stressors (e.g. nuclear factor kB). Moreover, collaborative findings indicate thatblueberry or Concord grape juice supplementation in humans with mild cognitive impairment increased verbal memoryperformance, thus translating our animal findings to humans. Taken together, these results suggest that a greater intake ofhigh-antioxidant foods such as berries, Concord grapes, and walnuts may increase "health span" and enhance cognitiveand motor function in aging.