DECREASED BETA-ADRENERGIC RECEPTORS ON POLYMORPHONUCLEAR LEUKOCYTES AFTER ADRENERGIC THERAPY
DECREASED BETA-ADRENERGIC RECEPTORS ON POLYMORPHONUCLEAR LEUKOCYTES AFTER ADRENERGIC THERAPY
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DOI：
10.1056/nejm197810262991707
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发表时间：
1978-01-01
影响因子：
158.5
通讯作者：
INSEL, PA
中科院分区：
文献类型：
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作者：
GALANT, SP;DURISETI, L;INSEL, PA
β-肾上腺素能儿茶酚胺调节多种组织的功能，被认为最初通过与靶细胞膜上的受体结合起作用，从而激活腺苷酸环化酶并刺激腺苷3′：5′-单磷酸腺苷（环AMP）的产生。除了激活腺苷酸环化酶外，β-肾上腺素能激动剂通常还有第二个作用-调节靶细胞的反应性。因此，持续使用此类激动剂治疗通常会导致细胞反应降低。这种靶细胞反应性的自我调节，被不同地称为难治性、脱敏性和下调性，已经在儿茶酚胺以及许多其他激素激动剂中被观察到。对于儿茶酚胺，几个实验研究…
β-ADRENERGIC catecholamines, which modulate function of a variety of tissues, are assumed to act by initially binding to receptors on target-cell plasma membranes, thereby activating adenylate cyclase and stimulating generation of adenosine 3′:5′-monophosphate (cyclic AMP). In addition to activating adenylate cyclase, β-adrenergic agonists commonly have a second action — regulation of responsiveness of the target cells. Thus, continued treatment with such agonists often results in decreased cellular response. This self-regulation of target-cell responsiveness, variously termed refractoriness, desensitization and down-regulation, has been observed with catecholamines, as well as with a number of other hormonal agonists.123For catecholamines, studies in several experimental . . .