One-step patterning of hollow microstructures in paper by laser cutting to create microfluidic analytical devices
One-step patterning of hollow microstructures in paper by laser cutting to create microfluidic analytical devices
复制标题
通过激光切割对纸张中空微结构进行一步图案化，以创建微流体分析装置
DOI：
10.1039/c2an36219h
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发表时间：
2013-01-01
期刊：
影响因子：
4.2
通讯作者：
Zhang, Songbai
中科院分区：
文献类型：
--
作者：
Nie, Jinfang;Liang, Yuanzhi;Zhang, Songbai
在本文中，我们报告了一种简单、低成本的方法，利用商用的小型CO2激光切割/雕刻机快速、高重复性地制造纸基微流体。这种方法只需要按照预先设计的图案用激光切割一张纸的一次操作。本文所形成的中空微结构被用作“疏水屏障”来定义亲水流动路径。在一张4厘米x 4厘米的纸上制作一个典型的纸器可以在类似于S的7-20分钟内制造出来；一旦切割过程完成，它就可以使用了。对激光器的外加电流和切割速度等主要工艺参数进行了优化。对中空微结构图案纸的制备分辨率和多重分析能力进行了表征。
In this paper, we report a simple, low-cost method for rapid, highly reproductive fabrication of paper-based microfluidics by using a commercially available, minitype CO2 laser cutting/engraving machine. This method involves only one operation of cutting a piece of paper by laser according to a predesigned pattern. The hollow microstructures formed in the paper are used as the 'hydrophobic barriers' to define the hydrophilic flowing paths. A typical paper device on a 4 cm x 4 cm piece of paper can be fabricated within similar to 7-20 s; it is ready for use once the cutting process is finished. The main fabrication parameters such as the applied current and cutting rate of the laser were optimized. The fabrication resolution and multiplexed analytical capability of the hollow microstructure-patterned paper were also characterized.