Finasteride increases anagen hair in men with androgenetic alopecia
Finasteride increases anagen hair in men with androgenetic alopecia
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DOI：
10.1046/j.1365-2133.2000.03780.x
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发表时间：
2000-10-01
影响因子：
10.3
通讯作者：
Kaufman, KD
中科院分区：
文献类型：
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作者：
Van Neste, D;Fuh, V;Kaufman, KD
研究背景头发的生长是一个周期性的过程，包括生长期和休止期。在先前的雄激素性脱发男性临床试验中，用芬普胺治疗可增加特定区域的头皮毛发数量（即增加的毛发密度）。目的本研究使用光密度图方法来评估非那肽对毛发生长周期各阶段的影响。雄激素源性脱发患者随机接受非那雄胺1 mg/d或安慰剂治疗48周。在基线和24周和48周时，拍摄宏观照片以测量头皮1cm（2）目标区域中的毛发总数和毛发生长期毛发计数。结果在基线时，芬那肽组的平均毛发总数和毛发生长期毛发计数分别为200根和124根（%毛发生长期= 62%），毛发生长期与休止期的比率为1.74（几何平均值）。在安慰剂组中，相应值分别为196和119根毛发（%生长期= 60%）和1.57。在第48周，与安慰剂组相比，芬那肽组的毛发总数和毛发生长初期毛发数分别净改善（平均值+/- SE）17.3 +/- 2.5（8.3% +/- 1.4%）和27.0 +/- 2.9（26% +/- 3.1%）（P < 0.001）。此外，用非那肽治疗导致生长期与休止期比率的净改善为47%（P < 0.001）。在这项研究中，治疗与finespande 1毫克每天（-1）48周的总和生长期的头发数量增加，并提高了生长期休止期ratio.Conclusions这些数据提供了直接的证据，finespande 1毫克每天促进头发转化为生长期阶段。这些数据支持芬那肽治疗对头发质量产生有利影响，有助于在治疗患者中观察到的头发生长的明显改善。
Background The growth of scalp hair is a cyclical process of successive phases of growth (anagen) and rest (telogen). In previous clinical trials in men with androgenetic alopecia, treatment with finasteride increased scalp hair counts in a defined area (i.e. increased hair density).Objectives The current study used a phototrichogram methodology to assess the effect of finasteride on the phases of the hair growth cycle.Patients/Methods Two hundred and twelve men, age 18-40 years, with androgenetic alopecia were randomized to receive finasteride 1 mg daily or placebo for 48 weeks. At baseline and at 24 and 48 weeks, macrophotographs were taken to measure total and anagen hair count in a 1-cm(2) target area of the scalp.Results At baseline, mean total and anagen hair counts in the finasteride group were 200 and 124 hairs, respectively (% anagen = 62%) and the anagen to telogen ratio was 1.74 (geometric mean). In the placebo group, the respective values were 196 and 119 hairs (% anagen = 60%) and 1.57. At week 48, the finasteride group had a net improvement (mean +/- SE) compared with placebo in total and anagen hair counts of 17.3 +/- 2.5 hairs (8.3% +/- 1.4%) and 27.0 +/- 2.9 hairs (26% +/- 3.1%), respectively (P < 0.001). Furthermore, treatment with finasteride resulted in a net improvement in the anagen to telogen ratio of 47% (P < 0.001). In this study, treatment with finasteride 1 mg day(-1) for 48 weeks increased both total and anagen hair counts, and improved the anagen to telogen ratio.Conclusions These data provide direct evidence that finasteride 1 mg daily promotes the conversion of hairs into the anagen phase. These data support that finasteride treatment results in favourable effects on hair quality that contribute to the visible improvements in hair growth observed in treated patients.