Oxidative Stress at the Crossroads of Aging, Stroke and Depression.
Oxidative Stress at the Crossroads of Aging, Stroke and Depression.
复制标题
氧化应激处于衰老、中风和抑郁的十字路口
DOI：
10.14336/ad.2020.0225
复制
发表时间：
2020-12
影响因子：
7.4
通讯作者：
Zhang J
中科院分区：
文献类型：
--
作者：
Shao A;Lin D;Wang L;Tu S;Lenahan C;Zhang J
流行病学研究表明，在老龄化社会中，每3分42秒就有一人死于中风，全球有大量的人患有抑郁症。中风和抑郁症的高患病率和致残率给公共卫生带来了巨大挑战。越来越多的证据表明，中风与抑郁症密切相关，这两种疾病都与氧化应激（OS）有关。本文综述了脑卒中和抑郁症中OS及其介导的病理过程的机制，如炎症、细胞凋亡和微生物-肠-脑轴。病理改变可通过DNA损伤和脂质和蛋白质氧化导致神经元细胞死亡、神经功能缺损和脑损伤，从而加剧这两种疾病的发展。此外，衰老通过过度活跃的OS和减少抗氧化防御加速了中风和抑郁症的进展。本文还讨论了几种抗氧化剂和抗抑郁药对脑卒中和抑郁症的疗效和安全性。在此，我们提出了OS、衰老、中风和抑郁之间的串扰，并为中风和抑郁的治疗提供了潜在的治疗策略。
Epidemiologic studies have shown that in the aging society, a person dies from stroke every 3 minutes and 42 seconds, and vast numbers of people experience depression around the globe. The high prevalence and disability rates of stroke and depression introduce enormous challenges to public health. Accumulating evidence reveals that stroke is tightly associated with depression, and both diseases are linked to oxidative stress (OS). This review summarizes the mechanisms of OS and OS-mediated pathological processes, such as inflammation, apoptosis, and the microbial-gut-brain axis in stroke and depression. Pathological changes can lead to neuronal cell death, neurological deficits, and brain injury through DNA damage and the oxidation of lipids and proteins, which exacerbate the development of these two disorders. Additionally, aging accelerates the progression of stroke and depression by overactive OS and reduced antioxidant defenses. This review also discusses the efficacy and safety of several antioxidants and antidepressants in stroke and depression. Herein, we propose a crosstalk between OS, aging, stroke, and depression, and provide potential therapeutic strategies for the treatment of stroke and depression.