Dicer's Helicase Domain: A Meeting Place for Regulatory Proteins.
Dicer's Helicase Domain: A Meeting Place for Regulatory Proteins.
复制标题
DOI：
10.1101/sqb.2019.84.039750
复制
发表时间：
2019-01-01
期刊：
影响因子：
--
通讯作者：
Bass, Brenda L
中科院分区：
文献类型：
--
作者：
Hansen, Sarah R;Aderounmu, Adedeji M;Bass, Brenda L
The function of Dicer's helicase domain has been enigmatic since its discovery. Why do only some Dicers require ATP, despite a high degree of sequence conservation in their helicase domains? We discuss evolutionary considerations based on differences between vertebrate and invertebrate antiviral defense, and how the helicase domain has been co-opted in extant organisms as the binding site for accessory proteins. Many accessory proteins are double-stranded RNA binding proteins, and we propose models for how they modulate Dicer function and catalysis.
