Extraordinary parasite multiplication rates in human malaria infections
Extraordinary parasite multiplication rates in human malaria infections
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DOI：
10.1016/j.pt.2023.05.006
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发表时间：
2023-07-12
影响因子：
9.6
通讯作者：
Childs，Lauren M.
中科院分区：
文献类型：
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作者：
Greischar，Megan A.;Childs，Lauren M.
对于致病生物来说，更快的繁殖速度促进了传播的成功、对宿主的潜在伤害以及耐药性的进化。在疟疾感染中，由于取样相对容易，寄生虫增殖率（PMRs）经常被量化。利用现代和历史上的人类感染数据，我们表明，现有的方法返回的pmr非常大，而且令人难以置信。我们从疟疾生物学的两个方面说明了夸大的pmr是如何产生的，这些方面远非独一无二：(i)一些发育年龄比其他年龄更容易取样；（ii）发育年龄分布在感染过程中发生变化。准确量化pmr的困难表明，需要强有力的方法，并随后重新评估甚至在经过充分研究的疟疾系统中已知的情况。
For pathogenic organisms, faster rates of multiplication promote transmission success, the potential to harm hosts, and the evolution of drug resistance. Parasite multiplication rates (PMRs) are often quantified in malaria infections, given the relative ease of sampling. Using modern and historical human infection data, we show that established methods return extraordinarily – and implausibly – large PMRs. We illustrate how inflated PMRs arise from two facets of malaria biology that are far from unique: (i) some developmental ages are easier to sample than others; (ii) the distribution of developmental ages changes over the course of infection. The difficulty of accurately quantifying PMRs demonstrates a need for robust methods and a subsequent re-evaluation of what is known even in the well-studied system of malaria.