Chemoselective Conversion from α-Hydroxy Acids to α-Keto Acids Enabled by Nitroxyl-Radical-Catalyzed Aerobic Oxidation
Chemoselective Conversion from α-Hydroxy Acids to α-Keto Acids Enabled by Nitroxyl-Radical-Catalyzed Aerobic Oxidation
复制标题
DOI：
10.1021/acs.orglett.6b01964
复制
发表时间：
2016-09-02
期刊：
影响因子：
5.2
通讯作者：
Yamamoto, Yoshihiko
中科院分区：
文献类型：
--
作者：
Furukawa, Keisuke;Inada, Haruki;Yamamoto, Yoshihiko
研究了氮氧自由基催化剂2-氮杂金刚烷N-氧基（AZADO）催化α-羟基酸化学选择氧化为α-酮酸的反应。虽然α-酮酸是不稳定的，并且在氧化条件下可以容易地释放CO2，但是使用分子氧作为助氧化剂能够实现所需的化学选择性氧化。
The chemoselective oxidation of a-hydroxy acids to alpha-keto acids catalyzed by 2-azaadamantane N-oxyl (AZADO), a nitroxyl radical catalyst, is described. Although alpha-keto acids are labile and can easily release CO2 under oxidation conditions, the use of molecular oxygen as a cooxidant enables the desired chemoselective oxidation.